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Gene Expression Data
Assay Details
Assay
Reference: J:333559 Rupani DN, et al., Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling. Development. 2023 Jan 15;150(2):dev201097
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7539126
Gene symbol: Cga
Gene name: glycoprotein hormones, alpha subunit
Antibody: anti-Chr-A (C-12) (sc-393941)
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 2B Control: postnatal day 21; Adartm1Knk/?, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Ptf1a+/? (more )
Note: Multi-labeled: white - Cga; red - Amy (assay MGI:7539125); green - Krt19 (assay MGI:7539127); blue - hematoxylin. Control is either non-Cre-expressing OR Adar1 heterozygous litter mate.
Structure Cell Type Level Pattern Image Note
TS28: endocrine pancreas pancreatic endocrine cell Present 2B Control inset , 2B Control
Specimen 2B CYA: postnatal day 21; Adartm1Knk/Adartm1Knk, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Multi-labeled: white - Cga; red - Amy (assay MGI:7539125); green - Krt19 (assay MGI:7539127); blue - hematoxylin.
Structure Cell Type Level Pattern Image Note
TS28: endocrine pancreas pancreatic endocrine cell Strong Regionally restricted 2B CYA , 2B CYA inset Authors report an increase in endocrine cell area.
Specimen 4G Control: postnatal month 6; Adartm1Knk/Adar+, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Mavstm1Zjc/Mavstm1Zjc, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Multi-labeled: white - Cga; red - Amy (assay MGI:7539125); green - Krt19 (assay MGI:7539127); blue - hematoxylin. Control is either non-Cre-expressing OR Adar1 heterozygous litter mate.
Structure Cell Type Level Pattern Image Note
TS28: endocrine pancreas pancreatic endocrine cell Present 4G Control inset , 4G Control
Specimen 4G CYAM: postnatal month 6; Adartm1Knk/Adartm1Knk, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Mavstm1Zjc/Mavstm1Zjc, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Multi-labeled: white - Cga; red - Amy (assay MGI:7539125); green - Krt19 (assay MGI:7539127); blue - hematoxylin.
Structure Cell Type Level Pattern Image Note
TS28: endocrine pancreas pancreatic endocrine cell Present 4G CYAM , 4G CYAM inset No significant difference in endocrine cells compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory