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Gene Expression Data
Assay Details
Assay
Reference: J:336175 Fuchs MAA, et al., Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice. Am J Physiol Renal Physiol. 2022 Mar 1;322(3):F295-F307
Assay type: RNA in situ
MGI Accession ID: MGI:7531050
Gene symbol: Col1a1
Gene name: collagen, type I, alpha 1
Probe: Mm-Col1a1 (319371)
Probe preparation: Antisense
Visualized with: Fluorescence
Assay notes: RNAscope assay.
Results
Specimen 9 Wildtype: postnatal adult (more )
Note: Double labeled: red - Col1a1; green - Pdgfrb (assay MGI:7531043).
Structure Cell Type Level Pattern Image Note
TS28: renal interstitium kidney inner medulla interstitial cell Present Regionally restricted 9_Wildtype Expression exclusively in Pdgfrb-expressing interstitial cells. Lower degree of expression than in mutant mice.
Specimen 9 FoxD1+/Cre EP2-/- EP4f/f: postnatal adult; Foxd1tm1(GFP/cre)Amc/Foxd1+, Ptger2tm1Brey/Ptger2tm1Brey, Ptger4tm1.1Matb/Ptger4tm1.1Matb (more )
Note: Conditional mutant. Double labeled: red - Col1a1; green - Pdgfrb (assay MGI:7531043).
Structure Cell Type Level Pattern Image Note
TS28: renal interstitium kidney inner medulla interstitial cell Strong Regionally restricted 9_FoxD1+/Cre EP2-/- EP4f/f Strong expression in interstitial cells surrounding underdeveloped subcapsular glomeruli.
TS28: glomerular mesangium glomerular mesangial cell Absent 9_FoxD1+/Cre EP2-/- EP4f/f
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory