About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:224892 Yan Y, et al., Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Nat Commun. 2015;6:7006
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7520130
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Antibody: clone 51.4H9
Detection system: Secondary antibody
Assay notes: The specificity of the antibody used was not detailed; both family members have been annotated.
Results
Specimen 2g +/y: embryonic day 9.5 (more )
Note: Double labeled: red - Isl1 and Isl2; green - Olig2 (assay MGI:7520131).
Structure Cell Type Level Pattern Image Note
TS15: future spinal cord spinal cord motor neuron Present 2g Expressed in newly differentiating and and postmitotic motor neurons.
Specimen 2j -y or -/-: embryonic day 9.5; Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified. Double labeled: red - Isl1 and Isl2; green - Olig2 (assay MGI:7520131).
Structure Cell Type Level Pattern Image Note
TS15: future spinal cord spinal cord motor neuron Present 2j Expressed in newly differentiating and and postmitotic motor neurons.
Specimen 3j -y or -/-: embryonic day 9.5; Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified. Double labeled: red - Isl1 and Isl2; green - Olig2 (assay MGI:7520131).
Structure Cell Type Level Pattern Image Note
TS15: future spinal cord spinal cord motor neuron Present 3j Expressed in newly differentiating and and postmitotic motor neurons.
Specimen 3k: embryonic day 9.5; Gdpd5tm1.1Itl/Gdpd5+, Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified. Double labeled: red - Isl1 and Isl2; green - Olig2 (assay MGI:7520131).
Structure Cell Type Level Pattern Image Note
TS15: future spinal cord spinal cord motor neuron Present 3k The increase in Isl1/2+ cells observed in Prdx4 null animals was substantially reduced.
Specimen S3a +/y: embryonic day 13.5 (more )
Note: Double labeled: red - Isl1 and Isl2; green - Lhx3 (assay MGI:7520151).
Structure Cell Type Level Pattern Image Note
TS21: spinal cord ventral horn spinal cord motor neuron Present S3a
Specimen S3d -y or -/-: embryonic day 13.5; Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified. Double labeled: red - Isl1 and Isl2; green - Lhx3 (assay MGI:7520151).
Structure Cell Type Level Pattern Image Note
TS21: spinal cord ventral horn spinal cord motor neuron Present S3d Medial median motor column (MMCm, Isl1/2+Lhx3+) motor neuron numbers were similar as in the wild-type littermates.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory