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Gene Expression Data
Assay Details
Assay
Reference: J:338453 Kim MK, et al., Spatiotemporal and functional characterisation of transient receptor potential vanilloid 4 (TRPV4) in the murine intervertebral disc. Eur Cell Mater. 2021 Feb 23;41:194-203
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7516512
Gene symbol: Trpv4
Gene name: transient receptor potential cation channel, subfamily V, member 4
Reporter: lacZ
Direct Detection
Results
Specimen 2a E8.5: embryonic day 8.5; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Level Pattern Image Note
TS13: embryo Absent 2a E8.5 No expression at early stages of notochord formation and elongation.
Specimen 2a E12.5: embryonic day 12.5; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Level Pattern Image Note
TS20: axial skeleton Present 2a E12.5
TS20: limb Present 2a E12.5
TS20: medulla oblongata alar plate Present 2a E12.5
TS20: notochord Present 2a E12.5
Specimen 2a E17.5: embryonic day 17.5; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Level Pattern Image Note
TS25: limb cartilage condensation Present Regionally restricted 2a E17.5 Expression in cartilage primordium of mandible, limbs, ribs and spine.
TS25: mandible Present Regionally restricted 2a E17.5 Expression in cartilage primordium of mandible, limbs, ribs and spine.
TS25: rib Present Regionally restricted 2a E17.5 Expression in cartilage primordium of mandible, limbs, ribs and spine.
TS25: vertebral cartilage condensation Present Regionally restricted 2a E17.5 Expression in cartilage primordium of mandible, limbs, ribs and spine.
Specimen 2a PN1: postnatal day 1; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Level Pattern Image Note
TS27: limb skeleton Present Regionally restricted 2a PN1 Expression in cartilage primordium of mandible, limbs, ribs and spine.
TS27: mandible Present Regionally restricted 2a PN1 Expression in cartilage primordium of mandible, limbs, ribs and spine.
TS27: rib Present Regionally restricted 2a PN1 Expression in cartilage primordium of mandible, limbs, ribs and spine.
TS27: vertebra Present Regionally restricted 2a PN1 Expression in cartilage primordium of mandible, limbs, ribs and spine.
Specimen 2b notochord: embryonic day 12.5; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Level Pattern Image Note
TS20: notochord Present Patchy 2b notochord , 2b section
Specimen 2c lumbar: embryonic day 17.5; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Level Pattern Image Note
TS25: annulus fibrosus Present 2c lumbar , 2c section
TS25: lumbar intervertebral disc Present 2c lumbar , 2c section
TS25: nucleus pulposus Present 2c lumbar , 2c section
TS25: vertebral cartilage condensation Present 2c lumbar , 2c section
Specimen 2d lumbar: postnatal day 1; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Level Pattern Image Note
TS27: annulus fibrosus Present 2d lumbar , 2d section
TS27: nucleus pulposus Present 2d lumbar , 2d section
TS27: vertebra Present 2d lumbar , 2d section
Specimen 3b 2.5 months Thoracic: postnatal month 2.5; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Cell Type Level Pattern Image Note
TS28: annulus fibrosus Present 3b 2.5 months Thoracic Expression in nucleus pulposus and inner annulus fibrosus.
TS28: nucleus pulposus Present 3b 2.5 months Thoracic Expression in nucleus pulposus and inner annulus fibrosus.
TS28: thoracic vertebra hypertrophic chondrocyte Present 3b 2.5 months Thoracic Expression in hypertrophic chondrocytes throughout vertebral growth plates.
Specimen 3b 2.5 months Lumbar: postnatal month 2.5; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Cell Type Level Pattern Image Note
TS28: annulus fibrosus Present 3b 2.5 months Lumbar Expression in nucleus pulposus and inner annulus fibrosus.
TS28: nucleus pulposus Present 3b 2.5 months Lumbar Expression in nucleus pulposus and inner annulus fibrosus.
TS28: lumbar vertebra hypertrophic chondrocyte Present 3b 2.5 months Lumbar Expression in hypertrophic chondrocytes throughout vertebral growth plates.
Specimen 3b 2.5 months Tail tip: postnatal month 2.5; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Cell Type Level Pattern Image Note
TS28: annulus fibrosus Present 3b 2.5 months Tail tip Expression in nucleus pulposus and inner annulus fibrosus.
TS28: nucleus pulposus Present 3b 2.5 months Tail tip Expression in nucleus pulposus and inner annulus fibrosus.
TS28: tail vertebra hypertrophic chondrocyte Present 3b 2.5 months Tail tip Expression in hypertrophic chondrocytes throughout vertebral growth plates.
Specimen 3b 6 months Thoracic: postnatal month 6; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Cell Type Level Pattern Image Note
TS28: annulus fibrosus Weak 3b 6 months Thoracic Expression decreased with age. Less expression in nucleus pulposus and inner annulus fibrosus compared to 2.5 months.
TS28: nucleus pulposus Weak 3b 6 months Thoracic Expression decreased with age. Less expression in nucleus pulposus and inner annulus fibrosus compared to 2.5 months.
TS28: thoracic vertebra hypertrophic chondrocyte Present 3b 6 months Thoracic Expression in hypertrophic chondrocytes throughout vertebral growth plates.
Specimen 3b 6 months Lumbar: postnatal month 6; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Cell Type Level Pattern Image Note
TS28: annulus fibrosus Weak 3b 6 months Lumbar Expression decreased with age. Less expression in nucleus pulposus and inner annulus fibrosus compared to 2.5 months.
TS28: nucleus pulposus Weak 3b 6 months Lumbar Expression decreased with age. Less expression in nucleus pulposus and inner annulus fibrosus compared to 2.5 months.
TS28: lumbar vertebra hypertrophic chondrocyte Present 3b 6 months Lumbar Expression in hypertrophic chondrocytes throughout vertebral growth plates.
Specimen 3b 6 months Tail tip: postnatal month 6; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Cell Type Level Pattern Image Note
TS28: annulus fibrosus Weak 3b 6 months Tail tip Expression decreased with age. Less expression in nucleus pulposus and inner annulus fibrosus compared to 2.5 months.
TS28: nucleus pulposus Weak 3b 6 months Tail tip Expression decreased with age. Less expression in nucleus pulposus and inner annulus fibrosus compared to 2.5 months.
TS28: tail vertebra hypertrophic chondrocyte Present 3b 6 months Tail tip Expression in hypertrophic chondrocytes throughout vertebral growth plates.
Specimen 3b 9 months Thoracic: postnatal month 9; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Cell Type Level Pattern Image Note
TS28: annulus fibrosus Weak 3b 9 months Thoracic Expression future reduced by 9 months.
TS28: nucleus pulposus Weak 3b 9 months Thoracic Expression future reduced by 9 months.
TS28: thoracic vertebra hypertrophic chondrocyte Present 3b 9 months Thoracic Expression in hypertrophic chondrocytes throughout vertebral growth plates.
Specimen 3b 9 months Lumbar: postnatal month 9; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Cell Type Level Pattern Image Note
TS28: annulus fibrosus Weak 3b 9 months Lumbar Expression future reduced by 9 months.
TS28: nucleus pulposus Weak 3b 9 months Lumbar Expression future reduced by 9 months.
TS28: lumbar vertebra hypertrophic chondrocyte Present 3b 9 months Lumbar Expression in hypertrophic chondrocytes throughout vertebral growth plates.
Specimen 3b 9 months Tail tip: postnatal month 9; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Cell Type Level Pattern Image Note
TS28: annulus fibrosus Weak 3b 9 months Tail tip Expression future reduced by 9 months.
TS28: nucleus pulposus Weak 3b 9 months Tail tip Expression future reduced by 9 months.
TS28: tail vertebra hypertrophic chondrocyte Present 3b 9 months Tail tip Expression in hypertrophic chondrocytes throughout vertebral growth plates.
Specimen 3b 12 months Thoracic: postnatal month 12; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Cell Type Level Pattern Image Note
TS28: annulus fibrosus Trace Single cells 3b 12 months Thoracic Few expressing cells at 12 months.
TS28: nucleus pulposus Trace Single cells 3b 12 months Thoracic Few expressing cells at 12 months.
TS28: thoracic vertebra hypertrophic chondrocyte Present 3b 12 months Thoracic Expression in hypertrophic chondrocytes throughout vertebral growth plates.
Specimen 3b 12 months Lumbar: postnatal month 12; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Cell Type Level Pattern Image Note
TS28: annulus fibrosus Trace Single cells 3b 12 months Lumbar Few expressing cells at 12 months.
TS28: nucleus pulposus Trace Single cells 3b 12 months Lumbar Few expressing cells at 12 months.
TS28: lumbar vertebra hypertrophic chondrocyte Present 3b 12 months Lumbar Expression in hypertrophic chondrocytes throughout vertebral growth plates.
Specimen 3b 12 months Tail tip: postnatal month 12; Trpv4tm1b(KOMP)Wtsi/Trpv4+ (more )
Structure Cell Type Level Pattern Image Note
TS28: annulus fibrosus Trace Single cells 3b 12 months Tail tip Few expressing cells at 12 months.
TS28: nucleus pulposus Trace Single cells 3b 12 months Tail tip Few expressing cells at 12 months.
TS28: tail vertebra hypertrophic chondrocyte Present 3b 12 months Tail tip Expression in hypertrophic chondrocytes throughout vertebral growth plates.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory