Trpv4tm1b(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Trpv4tm1b(KOMP)Wtsi |
Name: |
transient receptor potential cation channel, subfamily V, member 4; targeted mutation 1b, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:7512882 |
Synonyms: |
Trpv4LacZ |
Gene: |
Trpv4 Location: Chr5:114760213-114796482 bp, - strand Genetic Position: Chr5, 55.99 cM, cytoband F
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Alliance: |
Trpv4tm1b(KOMP)Wtsi page
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IMPC: |
Trpv4 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:338453
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 114773224 of Chromosome 5 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 114773304. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:338453)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Trpv4 Mutation: |
58 strains or lines available
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Original: |
J:338453 Kim MK, et al., Spatiotemporal and functional characterisation of transient receptor potential vanilloid 4 (TRPV4) in the murine intervertebral disc. Eur Cell Mater. 2021 Feb 23;41:194-203 |
All: |
1 reference(s) |
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