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Gene Expression Data
Assay Details
Assay
Reference: J:238698 Kasparek P, et al., KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype. PLoS Genet. 2017 Jan;13(1):e1006566
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7484322
Gene symbol: Flg
Gene name: filaggrin
Antibody: anti-Filaggrin
Detection system: Secondary antibody
Results
Specimen 5B Flg wt: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: epidermis Present Regionally restricted 5B Flg wt inset , 5B Flg wt Presence of profilaggrin granules.
Specimen 5B Flg A135X/A135X: embryonic day 18.5; Spink5em1Rase/Spink5em1Rase (more )
Structure Level Pattern Image Note
TS26: epidermis Present Regionally restricted 5B Flg A135X/A135X , 5B Flg A135X/A135X inset Absence of profilaggrin granules.
Specimen 5B Flg Klk5-/-;A135X/A135X: embryonic day 18.5; Klk5tm1Rase/Klk5tm1Rase, Spink5em1Rase/Spink5em1Rase (more )
Structure Level Pattern Image Note
TS26: epidermis Present Regionally restricted 5B Flg Klk5-/-;A135X/A135X , 5B Flg Klk5-/-;A135X/A135X inset Presence of profilaggrin granules.
Specimen 5B Flg Klk7-/-;A135X/A135X: embryonic day 18.5; Klk7em1Rase/Klk7em1Rase, Spink5em1Rase/Spink5em1Rase (more )
Structure Level Pattern Image Note
TS26: epidermis Present Regionally restricted 5B Flg Klk7-/-;A135X/A135X , 5B Flg Klk7-/-;A135X/A135X inset Absence of profilaggrin granules.
Specimen 5B Flg Klk5-/-;Klk7-/-;A135X/A135X: embryonic day 18.5; Klk5tm1Rase/Klk5tm1Rase, Klk7em1Rase/Klk7em1Rase, Spink5em1Rase/Spink5em1Rase (more )
Structure Level Pattern Image Note
TS26: epidermis Present Regionally restricted 5B Flg Klk5-/-;Klk7-/-;A135X/A135X inset , 5B Flg Klk5-/-;Klk7-/-;A135X/A135X Presence of profilaggrin granules.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory