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Gene Expression Data
Assay Details
Assay
Reference: J:319706 Silachev D, et al., Mouse models characterize GNAO1 encephalopathy as a neurodevelopmental disorder leading to motor anomalies: from a severe G203R to a milder C215Y mutation. Acta Neuropathol Commun. 2022 Jan 28;10(1):9
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7425422
Gene symbol: Reln
Gene name: reelin
Antibody: Anti-Reelin [EPR22515-75] (ab230820)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen S4B +/+: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: frontal cortex Cajal-Retzius cell Present S4B +/+ Reelin , S4B +/+ Merged
Specimen S4B C215Y/+: embryonic day 18.5; Gnao1em2Katv/Gnao1+ (more )
Structure Cell Type Level Pattern Image Note
TS26: frontal cortex Cajal-Retzius cell Present S4B C215Y/+ Merged , S4B C215Y/+ Reelin
Specimen S4B C215Y/C215Y: embryonic day 18.5; Gnao1em2Katv/Gnao1em2Katv (more )
Structure Cell Type Level Pattern Image Note
TS26: frontal cortex Cajal-Retzius cell Present S4B C215Y/C215Y Merged , S4B C215Y/C215Y Reelin The decreased numbers of Reln-immunolabeled Cajal-Retzius cells was significantly different in the homozygous mutant compared with wild type.
Specimen S6C +/+: embryonic day 18.5 (more )
Note: Double labeled: red - Reln; green - Pou3f2 (assay MGI:7425428).
Structure Cell Type Level Pattern Image Note
TS26: frontal cortex Cajal-Retzius cell Present S6C +/+ Brn2/Reelin
Specimen S6C G203R/+: embryonic day 18.5; Gnao1em1Katv/Gnao1+ (more )
Note: Double labeled: red - Reln; green - Pou3f2 (assay MGI:7425428).
Structure Cell Type Level Pattern Image Note
TS26: frontal cortex Cajal-Retzius cell Present S6C G203R/+ Brn2/Reelin
Specimen S6C G203R/G203R: embryonic day 18.5; Gnao1em1Katv/Gnao1em1Katv (more )
Note: Double labeled: red - Reln; green - Pou3f2 (assay MGI:7425428).
Structure Cell Type Level Pattern Image Note
TS26: frontal cortex Cajal-Retzius cell Present Regionally restricted S6C G203R/G203R Brn2/Reelin Reln-positive cells in the marginal zone of the homozygous mutant were more numerous than in the heterozygous and wild type littermates.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory