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Gene Expression Data
Assay Details
Assay
Reference: J:331875 Wischhof L, et al., BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation. EMBO J. 2022 Dec 1;41(23):e110595
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7410997
Gene symbol: Dcx
Gene name: doublecortin
Results
Specimen 3E Nestin-Cre: postnatal adult; Tg(Nes-cre)1Kln/0 (more )
Note: Double labeled: white - Dcx; red - S100b (assay MGI:7410998).
Structure Level Pattern Image Note
TS28: hippocampus Present 3E Nestin-Cre
Specimen 3E fl/flNestin-Cre: postnatal adult; Bcl7atm1Ban/Bcl7atm1Ban, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Double labeled: white - Dcx; red - S100b (assay MGI:7410998).
Structure Level Pattern Image Note
TS28: hippocampus Weak Regionally restricted 3E fl/fl;Nestin-Cre Significant reduction in expressing cells, as well as cells co-labeled with EdU.
Specimen 3G Nestin-Cre: postnatal adult; Tg(Nes-cre)1Kln/0 (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present 3G Nestin-Cre
Specimen 3G fl/fl;Nestin-Cre: postnatal adult; Bcl7atm1Ban/Bcl7atm1Ban, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: dentate gyrus Weak Regionally restricted 3G fl/fl;Nestin-Cre Lower number, misalignment and reduced neuritic complexity of expressing cells compared to control.
Specimen EV3F Nestin-Cre: postnatal adult; Tg(Nes-cre)1Kln/0 (more )
Note: Double labeled: red - Dcx; green - Edu.
Structure Level Pattern Image Note
TS28: hippocampus Present EV3F Nestin-Cre DCX , EV3F Nestin-Cre (merge)
Specimen EV3F fl/fl;Nestin-Cre: postnatal adult; Bcl7atm1Ban/Bcl7atm1Ban, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Double labeled: red - Dcx; green - Edu.
Structure Level Pattern Image Note
TS28: hippocampus Present Regionally restricted EV3F fl/fl;Nestin-Cre DCX , EV3F fl/fl;Nestin-Cre (merge) Expressing cells misaligned with respect to granule cell layer of dentate gyrus.
Specimen EV4A wt/wt: postnatal adult (more )
Note: Double labeled: red - Dcx; green - Edu.
Structure Level Pattern Image Note
TS28: hippocampus Present EV4A wt/wt DCX , EV4A wt/wt (merge)
Specimen EV4A ko/ko: postnatal adult; Bcl7btm1.1Ban/Bcl7btm1.1Ban (more )
Note: Double labeled: red - Dcx; green - Edu.
Structure Level Pattern Image Note
TS28: hippocampus Present EV4A ko/ko DCX , EV4A ko/ko (merge) No detectable changes in numbers of expressing cells.
Specimen 3I fl/fl: postnatal adult; Bcl7atm1Ban/Bcl7atm1Ban (more )
Note: Double labeled: green - Dcx; red - Bcl7a (assay MGI:7410995).
Structure Level Pattern Image Note
TS28: hippocampus Present 3I fl/fl (merge) , 3I fl/fl DCX
Specimen 3I fl/fl;Baf53b-Cre: postnatal adult; Bcl7atm1Ban/Bcl7atm1Ban, Tg(Actl6b-cre)4092Jiwu/0 (more )
Note: Conditional mutant. Double labeled: green - Dcx; red - Bcl7a (assay MGI:7410995).
Structure Level Pattern Image Note
TS28: hippocampus Present 3I Baf53b-Cre (merge) , 3I Baf53b-Cre DCX
Specimen 3J fl/fl: postnatal adult; Bcl7atm1Ban/Bcl7atm1Ban (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present 3J fl/fl
Specimen 3J fl/fl;Baf53b-Cre: postnatal adult; Bcl7atm1Ban/Bcl7atm1Ban, Tg(Actl6b-cre)4092Jiwu/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: dentate gyrus Present 3J Baf53-Cre No obvious difference in number, morphology or alignment of expressing cells compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory