Tlx3 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:186470 Lopes C, et al., Tlx3 and runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors. J Neurosci. 2012 Jul 11;32(28):9706-15
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7388617
Gene symbol:	Tlx3
Gene name:	T cell leukemia, homeobox 3

Antibody:

anti-Tlx3

Results

1A ©

Specimen 1A: postnatal day 30 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: lumbar dorsal root ganglion	neuron	Present	Regionally restricted	1A	Expression in majority of small and medium diameter neurons, but excluded from subset of large and small neurons.

1B ©

Specimen 1B: postnatal day 30 (more

)
Note: Double labeled: green - Tlx3; red - TrkA (Ntrk1 assay MGI:7388618).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: lumbar dorsal root ganglion	neuron	Present	Regionally restricted	1B	Expression in 78% of Trka (Ntrk1)-expressing neurons.

1C ©

Specimen 1C: postnatal day 30 (more

)
Note: Double labeled: green - Tlx3; red - CGRP (Calca assay MGI:7388619).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: lumbar dorsal root ganglion	neuron	Present	Regionally restricted	1C	Expression in 76% of CGRP (Calca)-expressing neurons.

1D ©

Specimen 1D: postnatal day 30 (more

)
Note: Double labeled: green - Tlx3; red - IB4.

Structure	Cell Type	Level	Pattern	Image	Note
TS28: lumbar dorsal root ganglion	neuron	Present	Regionally restricted	1D	Expression in 92% of IB4-positive neurons.

1E ©

Specimen 1E: postnatal day 30 (more

)
Note: Double labeled: green - Tlx3; red - Runx1 (assay MGI:7388620).

Structure	Cell Type	Level	Pattern	Image	Note
TS28: lumbar dorsal root ganglion	neuron	Present	Regionally restricted	1E	Co-expression with Runx1 in 99% of neurons.

2G Control ©

Specimen 2G Control: postnatal day 30; Tlx3^tm2.1Qima/? (more

)
Note: Littermate control; genotype either fl/fl or fl/+.

Structure	Cell Type	Level	Pattern	Image	Note
TS28: lumbar dorsal root ganglion	neuron	Present	Regionally restricted	2G Control

Specimen 2G Tlx3F/F;Nav1.8Cre/+: postnatal day 30; Tlx3^tm2.1Qima/Tlx3^tm2.1Qima, Tg(Scn10a-cre)1Rkun/0 (more

)
Note: Conditional mutant.

Structure	Cell Type	Level	Pattern	Image	Note
TS28: lumbar dorsal root ganglion	neuron	Trace	Single cells	2G Tlx3F/F;Nav1.8Cre/+	Expression markedly reduced but not completely eliminated. Loss of expression in most lumbar dorsal root ganglia. Expression in only a few neurons.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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