Gene Expression Data
Assay Details
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Assay
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Reference:
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J:226736
Li X, et al., Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus. Antioxid Redox Signal. 2014 Oct 20;21(12):1675-92
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:7384794
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Gene symbol:
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Casp3
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Gene name:
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caspase 3
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Antibody:
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anti-activated Casp3
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Detection system:
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Secondary antibody coupled to Alexa Fluor
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Assay notes:
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The antibody used recognizes the activated form of the protein.
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Results
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Specimen
S6C +/+:
embryonic day 16.5
(more  )
Specimen
S6C +/+:
(close  )
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Genetic Background:
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involves: 129S4/SvJae * 129S6/SvEvTac
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: telencephalon |
Present |
Single cells |
S6C Foxo3a+/+;Fancd2+/+ Merge
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S6C Foxo3a+/+;Fancd2+/+
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Specimen
S6C Fancd2<-/->:
(close )
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Genetic Background:
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involves: 129S4/SvJae * 129S6/SvEvTac
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Mutant Allele(s):
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Fancd2tm1Hou/Fancd2tm1Hou
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: telencephalon |
Present |
Single cells |
S6C Foxo3a+/+;Fancd2-/-
,
S6C Foxo3a+/+;Fancd2-/- Merge
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In this mutant there is an increase in positive cells compared with wild type controls.
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Specimen
S6C Foxo3a<-/->:
(close )
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Genetic Background:
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involves: 129S4/SvJae * 129S6/SvEvTac
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Mutant Allele(s):
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Foxo3tm1.1Rdp/Foxo3tm1.1Rdp
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: telencephalon |
Present |
Single cells |
S6C Foxo3a-/-;Fancd2+/+
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S6C Foxo3a-/-;Fancd2+/+ Merge
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Expression in this mutant is similar to wild-type.
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Specimen
S6C DKO:
(close )
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: telencephalon |
Present |
Regionally restricted |
S6C Foxo3a-/-;Fancd2-/-
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S6C Foxo3a-/-;Fancd2-/- Merge
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In this mutant a large fraction of the brain had positive cells compared to wild-type.
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Analysis Tools
