Ret In situ reporter (knock in) Gene Expression Assay - GXD

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Gene Expression Data
Assay Details

Assay

Reference:	J:314923 Sunardi M, et al., Live visualization of a functional RET-EGFP chimeric receptor in homozygous knock-in mice. Dev Growth Differ. 2021 Aug;63(6):285-294
Assay type:	In situ reporter (knock in)
MGI Accession ID:	MGI:7378365
Gene symbol:	Ret
Gene name:	ret proto-oncogene

Reporter:	lacZ
	Direct Detection

Results

Specimen 2a: embryonic day 12.5; Ret^tm1Heno/Ret⁺ (more

)

Structure	Level	Pattern	Image	Note
TS20: enteric nervous system	Present		2a Ret^tauLacZ/+
TS20: metanephros	Present		2a Ret^tauLacZ/+
TS20: sympathetic ganglion	Present		2a Ret^tauLacZ/+

Specimen 2b: embryonic day 12.5; Ret^tm1Heno/Ret^tm1Heno (more

)

Structure	Level	Pattern	Image	Note
TS20: sympathetic ganglion	Present		2a Ret^{tauLacZ/tauLacZ}	This mutant has no enteric nervous system and kidneys and impaired development of the sympathetic ganglia.

Specimen 2c: embryonic day 12.5; Ret^tm1Heno/Ret^{tm6.1(RET/EGFP)Heno} (more

)

Structure	Level	Pattern	Image	Note
TS20: enteric nervous system	Present		2a Ret^{tauLacZ/RET-EGFP}	Expression in this mutant was similar to controls (Rettm1Heno/Ret+).
TS20: metanephros	Present		2a Ret^{tauLacZ/RET-EGFP}	Expression in this mutant was similar to controls (Rettm1Heno/Ret+).
TS20: sympathetic ganglion	Present		2a Ret^{tauLacZ/RET-EGFP}	Expression in this mutant was similar to controls (Rettm1Heno/Ret+).

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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