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Gene Expression Data
Assay Details
Assay
Reference: J:323190 Guo T, et al., KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis. Elife. 2022 Feb 25;11:e74595
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7367116
Gene symbol: Runx2
Gene name: runt related transcription factor 2
Results
Specimen 2I: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: palatal shelf mesenchyme Present 2I
Specimen 2J: embryonic day 13.5; Kdm6btm1.1Rbo/Kdm6btm1.1Rbo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: palatal shelf mesenchyme Weak Regionally restricted 2J Decrease in number of expressing cell compared to controls. Expression in fewer Edu-positive cells.
Specimen 2K: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: palatal shelf mesenchyme Present 2K
Specimen 2L: embryonic day 14.5; Kdm6btm1.1Rbo/Kdm6btm1.1Rbo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: palatal shelf mesenchyme Weak Regionally restricted 2L Decrease in number of expressing cell compared to controls. Expression in fewer Edu-positive cells.
Specimen 7E: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: palatal shelf Present 7E
Specimen 7F: embryonic day 13.5; Kdm6btm1.1Rbo/Kdm6btm1.1Rbo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: palatal shelf Weak 7F
Specimen 7G: embryonic day 13.5; Ezh2tm2Sho/Ezh2+, H2az2Tg(Wnt1-cre)11Rth/H2az2+, Kdm6btm1.1Rbo/Kdm6btm1.1Rbo (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: palatal shelf Present 7G Expression restored to normal levels.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory