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Gene Expression Data
Assay Details
Assay
Reference: J:200761 Kasberg AD, et al., SP8 regulates signaling centers during craniofacial development. Dev Biol. 2013 Sep 15;381(2):312-23
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7355999
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved caspase3
Detection system: Secondary antibody coupled to Alexa Fluor 555
Assay notes: Data was quantified in Fig 4A.
Results
Specimen S4A': embryonic day 8.5; Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS13: anterior neural ridge Present Single cells S4A/A'
TS13: neural crest neural crest cell Present Single cells S4A/A'
Specimen S4B': embryonic day 8.5; Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+, Sp8tm1Smb/Sp8tm1Smb, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS13: anterior neural ridge Present S4B/B' Three-fold increase compared with the wild-type.
TS13: neural crest neural crest cell Present Single cells S4B/B' Similar as in the wild-type.
Specimen S4C': embryonic day 9.5; Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS15: neural crest neural crest cell Present S4C/C'
Specimen S4D': embryonic day 9.5; Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+, Sp8tm1Smb/Sp8tm1Smb, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS15: neural crest neural crest cell Present S4D/D' Four-fold increase in the facial mesenchyme compared with the wild-type.
Specimen S4E: embryonic day 10.5; Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: latero-nasal process Present Single cells S4E
TS17: medial-nasal process Present Single cells S4E
TS17: nasal pit Present Single cells S4E
Specimen S4F: embryonic day 10.5; Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+, Sp8tm1Smb/Sp8tm1Smb, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: latero-nasal process Present S4F Significantly increased expression compared with the wild-type.
TS17: medial-nasal process Present S4F Significantly increased expression compared with the wild-type.
TS17: nasal pit Present S4F Significantly increased expression compared with the wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/24/2026
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