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Gene Expression Data
Assay Details
Assay
Reference: J:327815 Beauchamp MC, et al., Craniofacial Defects in Embryos with Homozygous Deletion of Eftud2 in Their Neural Crest Cells Are Not Rescued by Trp53 Deletion. Int J Mol Sci. 2022 Aug 12;23(16)
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7341543
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase-3 (Asp175; #9661)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 2D control: embryonic day 10.5; Eftud2em1Lajm/Eftud2em2Lajm, Trp53tm1Brn/Trp53+ (more )
Structure Level Pattern Image Note
TS17: brain Trace Regionally restricted 2D control Expression in neural tube anterior to rhombomere 4.
Specimen 2D Eftud2ncc-/-: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/E2f1+, Eftud2em1Lajm/Eftud2em2Lajm (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain Weak Regionally restricted 2D Eftud2ncc-/- Increased in expression compared to control not significant.
Specimen 2D Eftud2ncc-/-;Trp53ncc+/-: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/E2f1+, Eftud2em1Lajm/Eftud2em2Lajm, Trp53tm1Brn/Trp53+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain Strong 2D Eftud2ncc-/-;Trp53ncc+/- Significant increase in expressing cells compared to other genotypes.
Specimen 2D Eftud2ncc-/-;Trp53ncc-/-: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/E2f1+, Eftud2em1Lajm/Eftud2em2Lajm, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain Weak Regionally restricted 2D Eftud2ncc-/-;Trp53ncc-/- Increase in expression compared to controls no longer observed.
Specimen 2E control: embryonic day 10.5; Eftud2em1Lajm/Eftud2em2Lajm, Trp53tm1Brn/Trp53+ (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch Trace 2E control
Specimen 2E Eftud2ncc-/-: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/E2f1+, Eftud2em1Lajm/Eftud2em2Lajm (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: 1st branchial arch Trace 2E Eftud2ncc-/- Expression not significantly increased compared to controls.
Specimen 2E Eftud2ncc-/-;Trp53ncc+/-: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/E2f1+, Eftud2em1Lajm/Eftud2em2Lajm, Trp53tm1Brn/Trp53+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: 1st branchial arch Present 2E Eftud2ncc-/-;Trp53ncc+/- Expression not significantly increased compared to controls.
Specimen 2E Eftud2ncc-/-;Trp53ncc-/-: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/E2f1+, Eftud2em1Lajm/Eftud2em2Lajm, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: 1st branchial arch Trace 2E Eftud2ncc-/-;Trp53ncc-/- Expression not significantly increased compared to controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory