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Gene Expression Data
Assay Details
Assay
Reference: J:327815 Beauchamp MC, et al., Craniofacial Defects in Embryos with Homozygous Deletion of Eftud2 in Their Neural Crest Cells Are Not Rescued by Trp53 Deletion. Int J Mol Sci. 2022 Aug 12;23(16)
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7341542
Gene symbol: Trp53
Gene name: transformation related protein 53
Antibody: Anti-p53 (1C12) #2524
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 2B control: embryonic day 10.5; Eftud2em1Lajm/Eftud2em2Lajm, Trp53tm1Brn/Trp53+ (more )
Structure Level Pattern Image Note
TS17: brain Trace Regionally restricted 2B control Nuclear expression in neural tube anterior to rhombomere 4.
Specimen 2B Eftud2ncc-/-: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/E2f1+, Eftud2em1Lajm/Eftud2em2Lajm (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain Present 2B Eftud2ncc-/- Non-significant increase in expressing cells compared to controls or Eftud2ncc-/-;Trp53ncc-/- embryos.
Specimen 2B Eftud2ncc-/-;Trp53ncc+/-: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/E2f1+, Eftud2em1Lajm/Eftud2em2Lajm, Trp53tm1Brn/Trp53+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain Present 2B Eftud2ncc-/-;Trp53ncc+/- Non-significant increase in expressing cells compared to controls or Eftud2ncc-/-;Trp53ncc-/- embryos.
Specimen 2B Eftud2ncc-/-;Trp53ncc-/-: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/E2f1+, Eftud2em1Lajm/Eftud2em2Lajm, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain Weak Regionally restricted 2B Eftud2ncc-/-;Trp53ncc-/- Expression reduced compared to Eftud2ncc-/- embryos.
Specimen 2C control: embryonic day 10.5; Eftud2em1Lajm/Eftud2em2Lajm, Trp53tm1Brn/Trp53+ (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch Trace 2C control
Specimen 2C Eftud2ncc-/-: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/E2f1+, Eftud2em1Lajm/Eftud2em2Lajm (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: 1st branchial arch Trace 2C Eftud2ncc-/- No increase in expressing cells compared to controls or Eftud2ncc-/-;Trp53ncc-/- embryos
Specimen 2C Eftud2ncc-/-;Trp53ncc+/-: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/E2f1+, Eftud2em1Lajm/Eftud2em2Lajm, Trp53tm1Brn/Trp53+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: 1st branchial arch Trace 2C Eftud2ncc-/-;Trp53ncc+/- No increase in expressing cells compared to controls or Eftud2ncc-/-;Trp53ncc-/- embryos
Specimen 2C Eftud2ncc-/-;Trp53ncc-/-: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/E2f1+, Eftud2em1Lajm/Eftud2em2Lajm, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: 1st branchial arch Trace 2C Eftud2ncc-/-;Trp53ncc-/- Expression not affected by Trp53 genotype.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory