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Gene Expression Data
Assay Details
Assay
Reference: J:219823 Rosin JM, et al., Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination. Dev Biol. 2015 Mar 1;399(1):54-67
Assay type: RNA in situ
MGI Accession ID: MGI:7336394
Gene symbol: Bmp4
Gene name: bone morphogenetic protein 4
Probe: Bmp4 cDNA5
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 4G/G': postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: cerebellum external granule cell layer cerebellar granule cell Present 4G , 4G' granule cell precursors
TS27: cerebellum vermis lobule cerebellar granule cell Present 4G , 4G' granule cell precursors
Specimen 4H/H': postnatal day 0; Shox2tm1Ddu/Shox2tm1.1Ddu, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: cerebellum external granule cell layer cerebellar granule cell Present Regionally restricted 4H , 4H' Expression was up-regulated in the external granule cell layer.
TS27: cerebellum vermis lobule cerebellar granule cell Present Regionally restricted 4H , 4H' Expression was up-regulated in the external granule cell layer.
TS27: cerebellum Purkinje cell layer cerebellar granule cell Present Regionally restricted 4H , 4H' Expression was up-regulated in cells migrating inwards through the Purkinje cell layer, which were presumably post-mitotic granule cells in the vermis of the dorsal cerebellum in the mutant.
Specimen not shown: postnatal day 1 (more )
Note: Summarized in Fig 4M.
Structure Level Pattern Image Note
TS27: cerebellum external granule cell layer Present
TS27: cerebellum vermis lobule Present
Specimen not shown: postnatal day 1; Shox2tm1Ddu/Shox2tm1.1Ddu, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Summarized in Fig 4M.
Structure Cell Type Level Pattern Image Note
TS27: cerebellum external granule cell layer cerebellar granule cell Present Expression was up-regulated in the external granule cell layer.
TS27: cerebellum vermis lobule cerebellar granule cell Present Expression was up-regulated in the external granule cell layer.
TS27: cerebellum Purkinje cell layer cerebellar granule cell Present Expression was up-regulated in cells migrating inwards through the Purkinje cell layer, which were presumably post-mitotic granule cells in the vermis of the dorsal cerebellum in the mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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