Myo7a Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:248783 Xie WR, et al., An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment. J Neurosci. 2017 Sep 6;37(36):8583-8594
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7328543
Gene symbol:	Myo7a
Gene name:	myosin VIIA

Antibody:	anti-myosin VIIa (#25-6790)
Detection system:	Secondary antibody coupled to Alexa Fluor 594

Results

4B +/+ Mid/Base ©

Specimen 4B +/+ Mid/Base: postnatal month 2 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlea auditory hair cell	Present		4B +/+ Mid/Base

4B +/+ Apex ©

Specimen 4B +/+ Apex: postnatal month 2 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlea auditory hair cell	Present		4B +/+ Apex

4B lacZ/+ Mid/Base ©

Specimen 4B lacZ/+ Mid/Base: postnatal month 2; Atoh1^tm2Hzo/Atoh1⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlea auditory hair cell	Present		4B lacZ/+ Mid/Base	Authors report hair cell degeneration.

4B lacZ/+ Apex ©

Specimen 4B lacZ/+ Apex: postnatal month 2; Atoh1^tm2Hzo/Atoh1⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlea auditory hair cell	Present		4B lacZ/+ Apex	Authors report hair cell degeneration.

4B 193A/193A Mid/Base ©

Specimen 4B 183A/193A Mid/Base: postnatal month 2; Atoh1^tm7.1Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlea auditory hair cell	Present		4B 193A/193A Mid/Base	Authors report hair cell degeneration.

4B 193A/193A Apex ©

Specimen 4B 183A/193A Apex: postnatal month 2; Atoh1^tm7.1Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlea auditory hair cell	Present		4B 193A/193A Apex	Authors report hair cell degeneration.

4B 193A/lacZ Mid/Base ©

Specimen 4B 193A/lacZ Mid/Base: postnatal month 2; Atoh1^tm2Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlea auditory hair cell	Weak		4B 193A/lacZ Mid/Base	Hair cell degeneration most severe in S193A/lacZ mice.

4B 193A/lacZ Apex ©

Specimen 4B 193A/lacZ Apex: postnatal month 2; Atoh1^tm2Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlea auditory hair cell	Weak		4B 193A/lacZ Apex	Hair cell degeneration most severe in S193A/lacZ mice.

4C P0 LacZ/+ Base ©

Specimen 4C P0 lacZ/+ Base: postnatal day 0; Atoh1^tm2Hzo/Atoh1⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS27: cochlea	cochlear inner hair cell	Present		4C P0 LacZ/+ Base	Indistinguishable from wild type.
TS27: cochlea	cochlear outer hair cell	Present		4C P0 LacZ/+ Base	Indistinguishable from wild type.

4C P0 LacZ/+ Mid ©

Specimen 4C P0 lacZ/+ Mid: postnatal day 0; Atoh1^tm2Hzo/Atoh1⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS27: cochlea	cochlear inner hair cell	Present		4C P0 LacZ/+ Mid	Indistinguishable from wild type.
TS27: cochlea	cochlear outer hair cell	Present		4C P0 LacZ/+ Mid	Indistinguishable from wild type.

4C P0 LacZ/+ Apex ©

Specimen 4C P0 lacZ/+ Apex: postnatal day 0; Atoh1^tm2Hzo/Atoh1⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS27: cochlea	cochlear inner hair cell	Present		4C P0 LacZ/+ Apex	Indistinguishable from wild type.
TS27: cochlea	cochlear outer hair cell	Present		4C P0 LacZ/+ Apex	Indistinguishable from wild type.

4C P0 193A/193A Base ©

Specimen 4C P0 193A/193A Base: postnatal day 0; Atoh1^tm7.1Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS27: cochlea	cochlear inner hair cell	Present		4C P0 193A/193A Base	Indistinguishable from wild type.
TS27: cochlea	cochlear outer hair cell	Present		4C P0 193A/193A Base	Indistinguishable from wild type.

4C P0 193A/193A Mid ©

Specimen 4C P0 193A/193A Mid: postnatal day 0; Atoh1^tm7.1Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS27: cochlea	cochlear inner hair cell	Present		4C P0 193A/193A Mid	Indistinguishable from wild type.
TS27: cochlea	cochlear outer hair cell	Present		4C P0 193A/193A Mid	Indistinguishable from wild type.

4C P0 193A/193A Apex ©

Specimen 4C P0 193A/193A Apex: postnatal day 0; Atoh1^tm7.1Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS27: cochlea	cochlear inner hair cell	Present		4C P0 193A/193A Apex	Indistinguishable from wild type.
TS27: cochlea	cochlear outer hair cell	Present		4C P0 193A/193A Apex	Indistinguishable from wild type.

4C P0 193A/lacZ Base ©

Specimen 4C P0 193A/lacZ Base: postnatal day 0; Atoh1^tm2Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS27: cochlea	cochlear inner hair cell	Weak		4C P0 193A/lacZ Base	Earliest degeneration evident at P0.
TS27: cochlea	cochlear outer hair cell	Weak		4C P0 193A/lacZ Base	Earliest degeneration evident at P0.

4C P0 193A/lacZ Mid ©

Specimen 4C P0 193A/lacZ Mid: postnatal day 0; Atoh1^tm2Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS27: cochlea	cochlear inner hair cell	Weak		4C P0 193A/lacZ Mid	Earliest degeneration evident at P0.
TS27: cochlea	cochlear outer hair cell	Weak		4C P0 193A/lacZ Mid	Earliest degeneration evident at P0.

4C P0 193A/lacZ Apex ©

Specimen 4C P0 193A/lacZ Apex: postnatal day 0; Atoh1^tm2Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS27: cochlea	cochlear inner hair cell	Weak		4C P0 193A/lacZ Apex	Earliest degeneration evident at P0.
TS27: cochlea	cochlear outer hair cell	Weak		4C P0 193A/lacZ Apex	Earliest degeneration evident at P0.

4C P5 LacZ/+ Base ©

Specimen 4C P5 lacZ/+ Base: postnatal day 5; Atoh1^tm2Hzo/Atoh1⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Present		4C P5 LacZ/+ Base	Indistinguishable from wild type.
TS28: cochlea	cochlear outer hair cell	Present		4C P5 LacZ/+ Base	Indistinguishable from wild type.

4C P5 LacZ/+ Mid ©

Specimen 4C P5 lacZ/+ Mid: postnatal day 5; Atoh1^tm2Hzo/Atoh1⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Present		4C P5 LacZ/+ Mid	Indistinguishable from wild type.
TS28: cochlea	cochlear outer hair cell	Present		4C P5 LacZ/+ Mid	Indistinguishable from wild type.

4C P5 LacZ/+ Apex ©

Specimen 4C P5 lacZ/+ Apex: postnatal day 5; Atoh1^tm2Hzo/Atoh1⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Present		4C P5 LacZ/+ Apex	Indistinguishable from wild type.
TS28: cochlea	cochlear outer hair cell	Present		4C P5 LacZ/+ Apex	Indistinguishable from wild type.

4C P5 193A/193A Base ©

Specimen 4C P5 193A/193A Base: postnatal day 5; Atoh1^tm7.1Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Present		4C P5 193A/193A Base	Indistinguishable from wild type.
TS28: cochlea	cochlear outer hair cell	Present		4C P5 193A/193A Base	Indistinguishable from wild type.

4C P5 193A/193A Mid ©

Specimen 4C P5 193A/193A Mid: postnatal day 5; Atoh1^tm7.1Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Present		4C P5 193A/193A Mid	Indistinguishable from wild type.
TS28: cochlea	cochlear outer hair cell	Present		4C P5 193A/193A Mid	Indistinguishable from wild type.

4C P5 193A/193A Apex ©

Specimen 4C P5 193A/193A Apex: postnatal day 5; Atoh1^tm7.1Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Present		4C P5 193A/193A Apex	Indistinguishable from wild type.
TS28: cochlea	cochlear outer hair cell	Present		4C P5 193A/193A Apex	Indistinguishable from wild type.

4C P5 193A/lacZ Base ©

Specimen 4C P5 193A/lacZ Base: postnatal day 5; Atoh1^tm2Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Weak		4C P5 193A/lacZ Base
TS28: cochlea	cochlear outer hair cell	Weak		4C P5 193A/lacZ Base

4C P5 193A/lacZ Mid ©

Specimen 4C P5 193A/lacZ Mid: postnatal day 5; Atoh1^tm2Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Weak		4C P5 193A/lacZ Mid
TS28: cochlea	cochlear outer hair cell	Weak		4C P5 193A/lacZ Mid

4C P5 193A/lacZ Apex ©

Specimen 4C P5 193A/lacZ Apex: postnatal day 5; Atoh1^tm2Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Weak		4C P5 193A/lacZ Apex
TS28: cochlea	cochlear outer hair cell	Weak		4C P5 193A/lacZ Apex

4C P21 LacZ/+ Base ©

Specimen 4C P21 lacZ/+ Base: postnatal day 21; Atoh1^tm2Hzo/Atoh1⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Present		4C P21 LacZ/+ Base	Indistinguishable from wild type.
TS28: cochlea	cochlear outer hair cell	Present		4C P21 LacZ/+ Base	Indistinguishable from wild type.

4C P21 LacZ/+ Mid ©

Specimen 4C P21 lacZ/+ Mid: postnatal day 21; Atoh1^tm2Hzo/Atoh1⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Present		4C P21 LacZ/+ Mid	Indistinguishable from wild type.
TS28: cochlea	cochlear outer hair cell	Present		4C P21 LacZ/+ Mid	Indistinguishable from wild type.

4C P21 LacZ/+ Apex ©

Specimen 4C P21 lacZ/+ Apex: postnatal day 21; Atoh1^tm2Hzo/Atoh1⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Present		4C P21 LacZ/+ Apex	Indistinguishable from wild type.
TS28: cochlea	cochlear outer hair cell	Present		4C P21 LacZ/+ Apex	Indistinguishable from wild type.

4C P21 193A/193A Base ©

Specimen 4C P21 193A/193A Base: postnatal day 21; Atoh1^tm7.1Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Present		4C P21 193A/193A Base	Begins to exhibit hair cell loss.
TS28: cochlea	cochlear outer hair cell	Present		4C P21 193A/193A Base	Begins to exhibit hair cell loss.

Specimen 4C P21 193A/193A Mid: postnatal day 21; Atoh1^tm7.1Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Present		4C P21 193A/193A Mid	Begins to exhibit hair cell loss.
TS28: cochlea	cochlear outer hair cell	Present		4C P21 193A/193A Mid	Begins to exhibit hair cell loss.

Specimen 4C P21 193A/193A Apex: postnatal day 21; Atoh1^tm7.1Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Present		4C P21 193A/193A Apex	Begins to exhibit hair cell loss.
TS28: cochlea	cochlear outer hair cell	Present		4C P21 193A/193A Apex	Begins to exhibit hair cell loss.

Specimen 4C P21 193A/lacZ Base: postnatal day 21; Atoh1^tm2Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Weak		4C P21 193A/lacZ Base
TS28: cochlea	cochlear outer hair cell	Weak		4C P21 193A/lacZ Base

Specimen 4C P21 193A/lacZ Mid: postnatal day 21; Atoh1^tm2Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Weak		4C P21 193A/lacZ Mid
TS28: cochlea	cochlear outer hair cell	Weak		4C P21 193A/lacZ Mid

Specimen 4C P21 193A/lacZ Apex: postnatal day 21; Atoh1^tm2Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cochlea	cochlear inner hair cell	Weak		4C P21 193A/lacZ Apex
TS28: cochlea	cochlear outer hair cell	Weak		4C P21 193A/lacZ Apex

Specimen 5B Macula (utricle) Wild type: postnatal month 2 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: macula of utricle	macular hair cell	Present		5B Macula Wildtype

Specimen 5B Macula (utricle) lacZ/+: postnatal month 2; Atoh1^tm2Hzo/Atoh1⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: macula of utricle	macular hair cell	Present		5B Macula lacZ/+

Specimen 5B Macula (utricle) 193A/193A: postnatal month 2; Atoh1^tm7.1Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: macula of utricle	macular hair cell	Present		5B Macula 193A/193A	Authors report normal hair cell density compared with controls

Specimen 5B Macula (utricle) 193A/lacZ: postnatal month 2; Atoh1^tm2Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: macula of utricle	macular hair cell	Present		5B Macula 193A/lacZ	Authors report normal hair cell density compared with controls

Specimen 5B Cristae Wild type: postnatal month 2 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: crista ampullaris	vestibular hair cell	Present		5B Cristae Wildtype

Specimen 5B Cristae lacZ/+: postnatal month 2; Atoh1^tm2Hzo/Atoh1⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: crista ampullaris	vestibular hair cell	Present		5B Cristae lacZ/+

Specimen 5B Cristae l193A/193A: postnatal month 2; Atoh1^tm7.1Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: crista ampullaris	vestibular hair cell	Present		5B Cristae 193A/193A	Authors report normal hair cell density compared with controls

Specimen 5B Cristae l193A/lacZ: postnatal month 2; Atoh1^tm2Hzo/Atoh1^tm7.1Hzo (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: crista ampullaris	vestibular hair cell	Present		5B Cristae 193A/lacZ	Authors report normal hair cell density compared with controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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