Atoh1^tm7.1Hzo
Targeted Allele Detail

Summary

• Symbol: Atoh1^tm7.1Hzo
• Name: atonal bHLH transcription factor 1; targeted mutation 7.1, Huda Y Zoghbi
• MGI ID: MGI:5903210
• Synonyms: Atoh1-EGFP-S193A, Atoh1-S193A
• Gene: Atoh1 Location: Chr6:64706109-64708229 bp, + strand Genetic Position: Chr6, 30.03 cM
• Alliance: Atoh1^tm7.1Hzo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248783
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Reporter)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The enhanced green fluorescent protein (EGFP) is fused to the 3' end of the gene, which carries a S193A (TCC->GCC) mutation, followed by an FRT-flanked PGK-neomycin selection cassette. Flp-mediated recombination removed the FRT-flanked neo cassette. GFP expression has been observed in cerebellar granule neurons, deep cerebellar nuclei, hindbrain nuclei, spinal cord interneurons, secretory intestinal cells, Merkel cells, and inner ear hair cells. (J:248783)

Expression

In Mice Carrying this Mutation:

72 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atoh1 Mutation: 36 strains or lines available

References

• Original: J:248783 Xie WR, et al., An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment. J Neurosci. 2017 Sep 6;37(36):8583-8594
• All: 2 reference(s)