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Gene Expression Data
Assay Details
Assay
Reference: J:326587 Hurley S, et al., Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development. Mol Autism. 2021 Feb 24;12(1):16
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7316759
Gene symbol: Dcx
Gene name: doublecortin
Antibody: anti-doublecortin
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 6n: embryonic day 12.5; Chd8tm1.1Mabn/Chd8tm1.1Mabn (more )
Structure Level Pattern Image Note
TS20: telencephalon Present Regionally restricted 6n Expression at pial surface.
Specimen 6n': embryonic day 12.5; Chd8tm1.1Mabn/Chd8tm1.1Mabn (more )
Structure Level Pattern Image Note
TS20: cortical preplate Present Regionally restricted 6n' Expression at pial surface.
Specimen 6o: embryonic day 12.5; Chd8tm1.1Mabn/Chd8tm1.1Mabn, Sox1tm1(cre)Take/Sox1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: telencephalon Present Regionally restricted 6o
Specimen 6o': embryonic day 12.5; Chd8tm1.1Mabn/Chd8tm1.1Mabn, Sox1tm1(cre)Take/Sox1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: cerebral cortex ventricular layer Present Regionally restricted 6o' Ectopic clusters of cells throughout neural tube, includng ventricular zone.
TS20: cortical preplate Present Regionally restricted 6o' Ectopic clusters of cells throughout neural tube, includng ventricular zone.
Specimen 6p: embryonic day 12.5; Chd8tm1.1Mabn/Chd8tm1.1Mabn, Sox1tm1(cre)Take/Sox1+, Trp53tm1Brn/Trp53+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: telencephalon Present Regionally restricted 6p Authors report that positioning of expressing cells was normalized.
Specimen 6p': embryonic day 12.5; Chd8tm1.1Mabn/Chd8tm1.1Mabn, Sox1tm1(cre)Take/Sox1+, Trp53tm1Brn/Trp53+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: cortical preplate Present Regionally restricted 6p' Authors report that positioning of expressing cells was normalized.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory