Chd8^tm1.1Mabn
Targeted Allele Detail

Summary

• Symbol: Chd8^tm1.1Mabn
• Name: chromodomain helicase DNA binding protein 8; targeted mutation 1.1, Michiel A Basson
• MGI ID: MGI:6115343
• Synonyms: Chd8^flox
• Gene: Chd8 Location: Chr14:52435608-52495237 bp, - strand Genetic Position: Chr14, 26.84 cM
• Alliance: Chd8^tm1.1Mabn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261980
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 3 was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:261980)

Expression

In Mice Carrying this Mutation:

20 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Chd8 Mutation: 107 strains or lines available

References

• Original: J:261980 Suetterlin P, et al., Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in Chd8 Haploinsufficient Mice. Cereb Cortex. 2018 Jun 1;28(6):2192-2206
• All: 3 reference(s)