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Gene Expression Data
Assay Details
Assay
Reference: J:326587 Hurley S, et al., Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development. Mol Autism. 2021 Feb 24;12(1):16
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7316757
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved-caspase-3
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 4c: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: neocortex Trace Single cells 4c
Specimen neo/+ not shown: embryonic day 14.5; Chd8tm1Mabn/Chd8+ (more )
Structure Level Pattern Image Note
TS22: neocortex Trace Single cells
Specimen 4d: embryonic day 14.5; Chd8tm1Mabn/Chd8tm1Mabn (more )
Structure Level Pattern Image Note
TS22: neocortex Trace Single cells 4d
Specimen 4e: embryonic day 14.5; Chd8tm1Mabn/Chd8tm1.2Mabn (more )
Structure Level Pattern Image Note
TS22: neocortex Present Scattered 4e inset , 4e Small increase in number of expressing cells compared with neo/neo and control embryos.
Specimen 6e: embryonic day 12.5; Chd8tm1.1Mabn/Chd8tm1.1Mabn (more )
Structure Level Pattern Image Note
TS20: neocortex Absent 6e
Specimen 6f: embryonic day 12.5; Chd8tm1.1Mabn/Chd8tm1.1Mabn, Sox1tm1(cre)Take/Sox1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Strong 6f Substantial increase in expression compared to control embryos.
Specimen 6g: embryonic day 12.5; Chd8tm1.1Mabn/Chd8tm1.1Mabn, Sox1tm1(cre)Take/Sox1+, Trp53tm1Brn/Trp53+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Present 6g Significant reduction in expression in pallium compared to cKO embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory