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Gene Expression Data
Assay Details
Assay
Reference: J:218166 Zhulyn O, et al., Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development. Dev Biol. 2015 Jan 15;397(2):191-202
Assay type: RNA in situ
MGI Accession ID: MGI:7256487
Gene symbol: Col2a1
Gene name: collagen, type II, alpha 1
Probe: Col2a1 probe26
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen S3A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: limb pre-cartilage condensation Present S3A
Specimen S3B: embryonic day 12.5; Ptch2tm1Bjw/Ptch2tm1Bjw (more )
Structure Level Pattern Image Note
TS20: limb pre-cartilage condensation Present S3B Digit pattern is not affected.
Specimen 5D': embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: forelimb pre-cartilage condensation Present 5D'
Specimen 5E': embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hindlimb pre-cartilage condensation Present 5E'
Specimen 5F: embryonic day 12.5; Ptch1tm1Bjw/Ptch1tm1.1Bjw, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: forelimb pre-cartilage condensation Present 5F' No gross changes in pattern of digits compared with wildtype.
Specimen 5G': embryonic day 12.5; Ptch1tm1Bjw/Ptch1tm1.1Bjw, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: hindlimb pre-cartilage condensation Present 5G' No gross changes in pattern of digits compared with wildtype.
Specimen 5H': embryonic day 12.5; Ptch1tm1Bjw/Ptch1tm1Mps, Ptch2tm1Bjw/Ptch2tm1Bjw, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: forelimb pre-cartilage condensation Present 5H' No gross changes in pattern of digits compared with wildtype.
Specimen 5I': embryonic day 12.5; Ptch1tm1Bjw/Ptch1tm1Mps, Ptch2tm1Bjw/Ptch2tm1Bjw, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: hindlimb pre-cartilage condensation Present 5I' No gross changes in pattern of digits compared with wildtype.
Specimen 7A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: limb pre-cartilage condensation Present 7A
Specimen 7B: embryonic day 12.5; Ptch1tm1Bjw/Ptch1tm1.1Bjw, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: limb mesenchyme Present Regionally restricted 7B Progressive truncaton of limb and digit loss.
Specimen 7C: embryonic day 12.5; Ptch1tm1Bjw/Ptch1tm1.1Bjw, Ptch2tm1Hui/Ptch2tm1Hui, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: limb mesenchyme Present Regionally restricted 7C Progressive truncaton of limb and digit loss.
Specimen S6A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: forelimb pre-cartilage condensation Present S6A
Specimen S6A': embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hindlimb pre-cartilage condensation Present S6A'
Specimen S6B: embryonic day 12.5; Ptch1tm1Bjw/Ptch1tm1.1Bjw, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: forelimb mesenchyme Present S6B Digit loss and outgrowth effects exacerbated by loss of Ptch2 in dose-dependent manner.
Specimen S6B': embryonic day 12.5; Ptch1tm1Bjw/Ptch1tm1.1Bjw, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: hindlimb mesenchyme Present S6B' Digit loss and outgrowth effects exacerbated by loss of Ptch2 in dose-dependent manner.
Specimen S6C: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: forelimb mesenchyme Present S6C Digit loss and outgrowth effects exacerbated by loss of Ptch2 in dose-dependent manner.
Specimen S6C': embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hindlimb mesenchyme Present S6C' Digit loss and outgrowth effects exacerbated by loss of Ptch2 in dose-dependent manner.
Specimen S6D: embryonic day 12.5; Ptch1tm1Bjw/Ptch1tm1.1Bjw, Ptch2tm1Hui/Ptch2tm1Hui, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: forelimb mesenchyme Present S6D Digit loss and outgrowth effects exacerbated by loss of Ptch2 in dose-dependent manner.
Specimen S6D': embryonic day 12.5; Ptch1tm1Bjw/Ptch1tm1.1Bjw, Ptch2tm1Hui/Ptch2tm1Hui, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: hindlimb mesenchyme Present S6D' Digit loss and outgrowth effects exacerbated by loss of Ptch2 in dose-dependent manner.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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