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Gene Expression Data
Assay Details
Assay
Reference: J:274050 Abramowski V, et al., PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice. Cell Death Differ. 2018 Feb;25(2):444-452
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6885903
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-CC3
Assay notes: The antibody used recognizes the cleaved form of the protein.
Results
Specimen 3c WT: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: ganglionic eminence Absent 3c WT Absent assigned by curator.
Specimen 3c PAXX-/-: embryonic day 12.5; Paxxem1Jpdv/Paxxem1Jpdv (more )
Note: The authors did not specify which mutant was used; both have been annotated.
Structure Level Pattern Image Note
TS20: ganglionic eminence Present Single cells 3c PAXX-/-
TS20: neocortex Present Single cells 3c PAXX-/-
Specimen 3c PAXX-/-: embryonic day 12.5; Paxxem2Jpdv/Paxxem2Jpdv (more )
Note: The authors did not specify which mutant was used; both have been annotated.
Structure Level Pattern Image Note
TS20: ganglionic eminence Present Single cells
TS20: neocortex Present Single cells
Specimen 3c Xlf-/-: embryonic day 12.5; Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS20: ganglionic eminence Absent 3c Xlf-/- Absent assigned by curator.
Specimen 3c PAXX-/-;Xlf-/-: embryonic day 12.5; Nhej1tm1Fwa/Nhej1tm1Fwa, Paxxem1Jpdv/Paxxem1Jpdv (more )
Note: The authors did not specify which mutant was used; both have been annotated.
Structure Level Pattern Image Note
TS20: ganglionic eminence Present Regionally restricted 3c PAXX-/-;Xlf-/- Expression is in the intermediate zones of the ganglionic eminences.
Specimen 3c PAXX-/-;Xlf-/-: embryonic day 12.5; Nhej1tm1Fwa/Nhej1tm1Fwa, Paxxem2Jpdv/Paxxem2Jpdv (more )
Note: The authors did not specify which mutant was used; both have been annotated.
Structure Level Pattern Image Note
TS20: ganglionic eminence Present Regionally restricted Expression is in the intermediate zones of the ganglionic eminences.
Specimen 3d WT: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: telencephalon Absent 3d WT Absent assigned by curator.
Specimen 3d PAXX-/-: embryonic day 15.5; Paxxem1Jpdv/Paxxem1Jpdv (more )
Note: The authors did not specify which mutant was used; both have been annotated.
Structure Level Pattern Image Note
TS23: telencephalon Present Single cells 3d PAXX-/-
Specimen 3d PAXX-/-: embryonic day 15.5; Paxxem2Jpdv/Paxxem2Jpdv (more )
Note: The authors did not specify which mutant was used; both have been annotated.
Structure Level Pattern Image Note
TS23: telencephalon Present Single cells
Specimen 3d Xlf-/-: embryonic day 15.5; Nhej1tm1Fwa/Nhej1tm1Fwa (more )
Structure Level Pattern Image Note
TS23: telencephalon Absent 3d Xlf-/- Absent assigned by curator.
Specimen 3d PAXX-/-;Xlf-/-: embryonic day 15.5; Nhej1tm1Fwa/Nhej1tm1Fwa, Paxxem1Jpdv/Paxxem1Jpdv (more )
Note: The authors did not specify which mutant was used; both have been annotated.
Structure Level Pattern Image Note
TS23: cerebral cortex intermediate zone Present 3d PAXX-/-;Xlf-/-
TS23: cerebral cortex subventricular zone Present 3d PAXX-/-;Xlf-/-
TS23: cerebral cortex ventricular layer Present 3d PAXX-/-;Xlf-/-
TS23: cortical plate Present 3d PAXX-/-;Xlf-/-
TS23: telencephalon Present Regionally restricted 3d PAXX-/-;Xlf-/- Expression is dorsal.
Specimen 3d PAXX-/-;Xlf-/-: embryonic day 15.5; Nhej1tm1Fwa/Nhej1tm1Fwa, Paxxem2Jpdv/Paxxem2Jpdv (more )
Note: The authors did not specify which mutant was used; both have been annotated.
Structure Level Pattern Image Note
TS23: cerebral cortex intermediate zone Present
TS23: cerebral cortex subventricular zone Present
TS23: cerebral cortex ventricular layer Present
TS23: cortical plate Present
TS23: telencephalon Present Regionally restricted Expression is dorsal.
Specimen S3A Paxx1-/-: embryonic day 12.5; Paxxem1Jpdv/Paxxem1Jpdv (more )
Structure Level Pattern Image Note
TS20: ganglionic eminence Present Single cells S3A Paxx1-/-
TS20: neocortex Present Single cells S3A Paxx1-/-
Specimen S3A Paxx2-/-: embryonic day 12.5; Paxxem2Jpdv/Paxxem2Jpdv (more )
Structure Level Pattern Image Note
TS20: ganglionic eminence Present Single cells S3A Paxx2-/-
TS20: neocortex Present Single cells S3A Paxx2-/-
Specimen S3B Paxx1-/-;Xlf-/-: embryonic day 15.5; Nhej1tm1Fwa/Nhej1tm1Fwa, Paxxem1Jpdv/Paxxem1Jpdv (more )
Structure Level Pattern Image Note
TS23: cerebral cortex intermediate zone Present S3B top
TS23: cerebral cortex subventricular zone Present S3B top
TS23: cerebral cortex ventricular layer Present S3B top
TS23: cortical plate Present S3B top
TS23: telencephalon Present Regionally restricted S3B top Expression is dorsal.
Specimen S3B Paxx2-/-;Xlf-/-: embryonic day 15.5; Nhej1tm1Fwa/Nhej1tm1Fwa, Paxxem2Jpdv/Paxxem2Jpdv (more )
Structure Level Pattern Image Note
TS23: cerebral cortex intermediate zone Present S3B bottom
TS23: cerebral cortex subventricular zone Present S3B bottom
TS23: cerebral cortex ventricular layer Present S3B bottom
TS23: cortical plate Present S3B bottom
TS23: telencephalon Present Regionally restricted S3B bottom Expression is dorsal.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/24/2026
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