Paxx^em2Jpdv
Endonuclease-mediated Allele Detail

Summary

• Symbol: Paxx^em2Jpdv
• Name: non-homologous end joining factor; endonuclease-mediated mutation 2, Jean-Pierre de Villartay
• MGI ID: MGI:6295840
• Synonyms: PAXX2
• Gene: Paxx Location: Chr2:25345153-25351106 bp, - strand Genetic Position: Chr2, 17.27 cM
• Alliance: Paxx^em2Jpdv page

Mutation origin

• Strain of Origin: (C57BL/6NCrl x CBA/CaCrl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 1 and 2 were targeted with gRNAs using CRISPR/Cas9 technology. This allele represents line #14 which has a 8 bp deletion in exon 2. Western blotting using protein extracts from thymus, spleen and MEFs showed the lack of expression from this allele. (J:274050)

Expression

In Mice Carrying this Mutation:

18 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Paxx Mutation: 9 strains or lines available

References

• Original: J:274050 Abramowski V, et al., PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice. Cell Death Differ. 2018 Feb;25(2):444-452
• All: 2 reference(s)