Ptch1 In situ reporter (knock in) Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:316551 Kwon YR, et al., The Shh coreceptor Cdo is required for differentiation of midbrain dopaminergic neurons. Stem Cell Res. 2014 Sep;13(2):262-74
Assay type:	In situ reporter (knock in)
MGI Accession ID:	MGI:6881732
Gene symbol:	Ptch1
Gene name:	patched 1

Reporter:	lacZ
	Direct Detection

Results

Specimen 4C Cdo+/+ (upper): embryonic day 9.5; Ptch1^tm1Mps/Ptch1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS15: future brain	Present	Regionally restricted	4C Cdo+/+ (upper)	Expression detected throughout ventral brain areas.

Specimen 4C Cdo-/- (upper): embryonic day 9.5; Cdon^tm1Rsk/Cdon^tm1Rsk, Ptch1^tm1Mps/Ptch1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS15: future brain	Weak	Regionally restricted	4C Cdo-/- (upper)	Intensity of expression in ventral brain significantly reduced compared to relative to Cdo+/+ brain.

Specimen 4C Cdo+/+ (lower): embryonic day 9.5; Ptch1^tm1Mps/Ptch1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS15: future midbrain	Present		4C Cdo+/+ (lower)

Specimen 4C Cdo-/- (lower): embryonic day 9.5; Cdon^tm1Rsk/Cdon^tm1Rsk, Ptch1^tm1Mps/Ptch1⁺ (more

)

Structure	Level	Pattern	Image	Note
TS15: future midbrain	Weak		4C Cdo-/- (lower)	Intensity of expression significantly reduced compared to relative to Cdo+/+ midbrain.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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