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Gene Expression Data
Assay Details
Assay
Reference: J:221408 Garriock RJ, et al., Lineage tracing of neuromesodermal progenitors reveals novel Wnt-dependent roles in trunk progenitor cell maintenance and differentiation. Development. 2015 May 1;142(9):1628-38
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6790448
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: Anti-Sox2 (Clone 245610; MAB2018)
Assay notes: The authors did not specify which Sox2 antibody was used, anti-Sox2 (AB5603) MGI:5762877 may have been used instead.
Results
Specimen 1B control: embryonic day 9.5 (more )
Note: Level of 13th-16th somite. Double labeled: green - Sox2; red - Fn1 (assay MGI:6790451).
Structure Level Pattern Image Note
TS15: nervous system Present 1B cont.
Specimen 1B Wnt3a-/-: embryonic day 9.5; Wnt3atm1Amc/Wnt3atm1Amc (more )
Note: Level of 13th-16th somite. Double labeled: green - Sox2; red - Fn1 (assay MGI:6790451).
Structure Level Pattern Image Note
TS15: nervous system Present 1B Wnt3a-/- This mutant has enlarged and malformed neural tissue.
Specimen 1F anterior: embryonic day 8.5 (more )
Note: Double labeled: green - Sox2; red - T (assay MGI:6790453).
Structure Level Pattern Image Note
TS13: primitive streak Present Regionally restricted 1F Sox2/T anterior , 1F Sox2 anterior Expression is in the epithelial primitive streak.
Specimen 1F posterior: embryonic day 8.5 (more )
Note: Double labeled: green - Sox2; red - T (assay MGI:6790453).
Structure Level Pattern Image Note
TS13: primitive streak Present Regionally restricted 1F Sox2 posterior , 1F Sox2/T posterior Expression is in the epithelial primitive streak and in ingressed cells of anterior, but not posterior, regions of the primitive streak.
Specimen 7A control: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: primitive streak Present Regionally restricted 7A control Sox2 Expression is in the anterior primitive streak in epithelialized streak and ingressed streak.
Specimen 7A Wnt3a-/-: embryonic day 8.5; Wnt3atm1Amc/Wnt3atm1Amc (more )
Structure Level Pattern Image Note
TS13: primitive streak Present Regionally restricted 7A Wnt3-/- Sox2 Expression is in the anterior primitive streak in epithelialized streak and ingressed streak.
Specimen S1E: embryonic day 8.5 (more )
Note: Double labeled: green - Sox2; red - T (assay MGI:6790453). Section is anterior to the primitive streak.
Structure Level Pattern Image Note
TS13: neural plate Present S1E Sox2 bottom , S1E Sox2 top , S1E Merge
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
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