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Gene Expression Data
Assay Details
Assay
Reference: J:217191 Zhang Y, et al., Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis. Dev Biol. 2014 Dec 1;396(1):19-30
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6763227
Gene symbol: Pax6
Gene name: paired box 6
Antibody: anti-Pax6 (#PRB-278P; #30130, #901301)
Detection system: Secondary antibody
Results
Specimen 1C E9.5 Control: embryonic day 9.5; Mdm2tm2.1Glo/Mdm2+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls.
Structure Level Pattern Image Note
TS15: lens pre-placode Present 1C E9.5 Control Expression in presumptive lens ectoderm.
Specimen 1C E9.5 M2 f/f; LE-Cre: embryonic day 9.5; Mdm2tm2.1Glo/Mdm2tm2.1Glo, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: lens pre-placode Present 1C E9.5 M2 f/f: LE-Cre Authors report surface ectoderm competent for presumptive lens was roughly normal
Specimen 3A PAX6 Control: embryonic day 10.0; Mdm2tm2.1Glo/Mdm2+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls.
Structure Level Pattern Image Note
TS16: lens pit Present 3A PAX6 Control
Specimen 3A PAX6 LE; M2 f/f: embryonic day 10.0; Mdm2tm2.1Glo/Mdm2tm2.1Glo, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS16: lens pit Present 3A PAX6 LE; M2 f/f Authors report no change in expression compared with control.
Specimen 3B PAX6 E10 Control: embryonic day 10.0; Mdm4tm2Glo/Mdm4+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls.
Structure Level Pattern Image Note
TS16: lens pit Present 3B PAX6 E10 Control
Specimen 3B PAX6 E10 LE; MX f/f: embryonic day 10.0; Mdm4tm2Glo/Mdm4tm2Glo, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS16: lens pit Present 3B PAX6 E10 LE; MX f/f Authors report no change in expression compared with control.
Specimen 3B PAX6 E10.5 Control: embryonic day 10.5; Mdm4tm2Glo/Mdm4+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls.
Structure Level Pattern Image Note
TS17: lens pit Present 3B PAX6 E10.5 Control
Specimen 3B PAX6 E10.5 LE: MX f/f: embryonic day 10.5; Mdm4tm2Glo/Mdm4tm2Glo, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: lens pit Present 3B PAX6 E10.5 LE; MX f/f Authors report no change in expression compared with control.
Specimen 3B PAX6 E11 Control: embryonic day 11.0; Mdm4tm2Glo/Mdm4+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls.
Structure Level Pattern Image Note
TS18: lens vesicle Present 3B PAX6 E11 Control
Specimen 3B PAX6 E11 LE; MX f/f: embryonic day 11.0; Mdm4tm2Glo/Mdm4tm2Glo, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS18: lens pit Present 3B PAX6 E11 LE; MX f/f Authors report no change in expression compared with control.
Specimen 5A PAX6 Control: embryonic day 10.0; Mdm2tm2.1Glo/Mdm2+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls. Triple labeled: red - Pax6; green - BrdU; blue - DAPI.
Structure Level Pattern Image Note
TS16: lens pit Present 5A PAX6 Control , 5A Control Merge , 5A Control (E10)
Specimen 5A PAX6 LE; M2 f/f: embryonic day 10.0; Mdm2tm2.1Glo/Mdm2tm2.1Glo, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant. Triple labeled: red - Pax6; green - BrdU; blue - DAPI.
Structure Level Pattern Image Note
TS16: lens placode Present 5A PAX6 LE; M2 f/f , 5A LE; M2 f/f Merge , 5A LE; M2 f/f (E10)
Specimen 5B PAX6 Control: embryonic day 10.5; Mdm4tm2Glo/Mdm4+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+ , Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls. Triple labeled: red - Pax6; green - BrdU; blue - DAPI.
Structure Level Pattern Image Note
TS17: lens vesicle Present 5B Control (E10.5) , 5B Control Merge , 5B PAX6 Control
Specimen 5B PAX6 LE; MX f/f: embryonic day 10.5; Mdm4tm2Glo/Mdm4tm2Glo, Tg(Pax6-cre,GFP)1Pgr/0, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Triple labeled: red - Pax6; green - BrdU; blue - DAPI.
Structure Level Pattern Image Note
TS17: lens pit Present 5B PAX6 LE; MX f/f , 5B LE; MX f/f (E10.5) , 5B LE; MX f/f Merge
Specimen 7B PAX6 Control: embryonic day 10.5; Mdm2tm2.1Glo/Mdm2+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls.
Structure Level Pattern Image Note
TS17: lens pit Present 7B PAX6 Control , 7B Control Merge
Specimen 7B PAX6 LE; M2 f/f; p53 f/f: embryonic day 10.5; Mdm2tm2.1Glo/Mdm2tm2.1Glo, Tg(Pax6-cre,GFP)1Pgr/0, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: lens pit Present 7B LE; M2 f/f; p53 f/f Merge , 7B PAX6 LE; M2 f/f; p53 f/f
Specimen 8A PAX6 Control: embryonic day 12.5; Mdm4tm2Glo/Mdm4+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls.
Structure Level Pattern Image Note
TS20: lens vesicle Present 8A PAX6 Control
Specimen 8A PAX6 LE; MX f/f; p53 f/f: embryonic day 12.5; Mdm4tm2Glo/Mdm4tm2Glo, Tg(Pax6-cre,GFP)1Pgr/0, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: lens vesicle Present 8B LE; MX f/f; p53 f/f Merge , 8A PAX6 LE; MX f/f; p53 f/f
Specimen 8B PAX6 Control: embryonic day 12.5; Mdm4tm2Glo/Mdm4+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls. Triple labeled: red - Pax6; green - Mki67 (assay MGI:6763230); blue - DAPI.
Structure Level Pattern Image Note
TS20: lens vesicle Present 8B Control Merge , 8B PAX6 Control
Specimen 8B PAX6 LE; MX f/f; p53 f/f: embryonic day 12.5; Mdm4tm2Glo/Mdm4tm2Glo, Tg(Pax6-cre,GFP)1Pgr/0, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Triple labeled: red - Pax6; green - Mki67 (assay MGI:6763230); blue - DAPI.
Structure Level Pattern Image Note
TS20: lens vesicle Present 8B PAX6 LE; MX f/f; p53 f/f
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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