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Gene Expression Data
Assay Details
Assay
Reference: J:217191 Zhang Y, et al., Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis. Dev Biol. 2014 Dec 1;396(1):19-30
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6763230
Gene symbol: Mki67
Gene name: antigen identified by monoclonal antibody Ki 67
Antibody: anti-ki67
Detection system: Secondary antibody
Results
Specimen 8B Ki67 Control: embryonic day 12.5; Mdm4tm2Glo/Mdm4+ (more )
Note: Authors report there were no obvious lens defects observed in Mdm2 f/+, Mdm2 f/f and Le-Cre; Mdm3 f/+ mice, and stated they combined the three groups for use as controls. Triple labeled: green - Mki67; red - Pax6 (assay MGI:6763227); blue - DAPI.
Structure Level Pattern Image Note
TS20: lens vesicle anterior epithelium Present 8B Ki67 Control , 8B Control Merge
Specimen 8B Ki67 LE; MX f/f; p53 f/f: embryonic day 12.5; Mdm4tm2Glo/Mdm4tm2Glo, Tg(Pax6-cre,GFP)1Pgr/0, Trp53tm1Brn/Trp53tm1Brn (more )
Note: Conditional mutant. Triple labeled: green - Mki67; red - Pax6 (assay MGI:6763227); blue - DAPI.
Structure Level Pattern Image Note
TS20: lens vesicle anterior epithelium Present 8B Ki67 LE; MX f/f; p53 f/f , 8B LE; MX f/f; p53 f/f Merge Authors report cell proliferation rate restored to 75% in MDMX (Mdm3) mutant mice.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
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