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Gene Expression Data
Assay Details
Assay
Reference: J:43437 Apte SS, et al., The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis. J Biol Chem. 1997 Oct 10;272(41):25511-7
Assay type: RNA in situ
MGI Accession ID: MGI:6714024
Gene symbol: Timp2
Gene name: tissue inhibitor of metalloproteinase 2
Probe: pmouseTIMP-2PCR
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen E7.5 not shown: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS11: embryo Absent

Specimen E9.5 not shown: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: embryo Absent

Specimen E10.5 not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: embryo Absent

Specimen uterus not shown: postnatal adult (more )
Structure Level Pattern Image Note
TS28: uterus Present Regionally restricted Distinct expression in uterus, particularly in endometrial glands and in myometrium at periphery of uterus.

Specimen 3B: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: dorsal aorta Present 3B Expression in aorta.

Specimen E12.5 not shown: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: arterial system Present Regionally restricted Expression in branches of aorta.
TS20: umbilical artery Present Regionally restricted Expression in smooth muscle cells of prospective arterial tunica media. No expression in endothelial layers.
TS20: mandibular process mesenchyme Strong Regionally restricted Higher expression in mesenchymal cells surrounding cartilage condensations for Meckel's cartilage and the claicle.
TS20: trunk mesenchyme Strong Regionally restricted Higher expression in mesenchymal cells surrounding cartilage condensations for Meckel's cartilage and the claicle.
TS20: nasal epithelium Present
TS20: liver Present Regionally restricted Expression in liver capsule.
TS20: mesenchyme of metanephros Present Regionally restricted Expression in differentiating mesenchyme in vicinity of prospective kidneys.

Specimen E14.5 not shown: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: musculoskeletal system Strong Strong expression in musculoskeletal system.

Specimen 5A: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: hindlimb mesenchyme Present Regionally restricted 5A Expression in musculotendinous structures in the leg.
TS25: perichondrium Strong Regionally restricted 5A Prominent expression in perichondrium; peak expression at point of transition of chondrocytes from small to hypertrophic cells.
TS25: hindlimb long bone Absent 5A No expression in metaphysis.
TS25: leg skin Present 5A

Specimen 6B: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: cruciate ligament of knee Strong Regionally restricted 6B Very prominent expression in anterior cruciate ligament and posterior cruciate ligament.
TS25: patellar ligament Present 6B Expression in patellar tendon.
TS25: articular cartilage Present Regionally restricted 6B Expression in superfical layers of articular cartilage.

Specimen 7C: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: dorsal root ganglion Strong 7C

Specimen 7D: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: trigeminal ganglion Strong 7D

Specimen E17.5 not shown: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: vestibulo-cochlear ganglion Strong
TS25: hip joint Strong Regionally restricted Strong expression in joint capsule of hip.
TS25: penis Present Regionally restricted Expression in cells in bulbospongiosus and corpora cavernosa of developing penis.

Specimen 8B (embryonic): embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: spongiotrophoblast Present 8B Expression in junctional area that includes decidual reaction of uterus and spongiotrophoblast of placenta.

Specimen 8B (maternal): embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS28: decidua Present 8B Expression in junctional area that includes decidual reaction of uterus and spongiotrophoblast of placenta.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory