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Gene Expression Data
Assay Details
Assay
Reference: J:159519 Saharinen P, et al., Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development. Genes Dev. 2010 May;24(9):875-80
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6501770
Gene symbol: Lyve1
Gene name: lymphatic vessel endothelial hyaluronan receptor 1
Antibody: anti-Lyve1
Results
Specimen 3A Clp24-/-: postnatal adult; Tmem204tm1.1Ali/Tmem204tm1.1Ali (more )
Note: Double labeled: red - Lyve1; green - Pecam1 (assay MGI:6501772).
Structure Level Pattern Image Note
TS28: ear Present Regionally restricted 3A Clp24 -/- Authors report enlarged lymphatic vessels.
TS28: lymphatic vessel Present Regionally restricted 3A Clp24 -/- Authors report enlarged lymphatic vessels.
Specimen 3A Clp24+/-: postnatal adult; Tmem204tm1.1Ali/Tmem204+ (more )
Note: Double labeled: red - Lyve1; green - Pecam1 (assay MGI:6501772).
Structure Level Pattern Image Note
TS28: ear Present Regionally restricted 3A Clp24 +/-
TS28: lymphatic vessel Present Regionally restricted 3A Clp24 +/-
Specimen 3B Clp24-/-: postnatal adult; Tmem204tm1.1Ali/Tmem204tm1.1Ali (more )
Structure Level Pattern Image Note
TS28: lymphatic vessel Present Regionally restricted 3B Clp24 -/- Authors report enlarged lymphatic vessels.
TS28: tongue Present Regionally restricted 3B Clp24 -/- Authors report enlarged lymphatic vessels.
Specimen 3B Clp24+/-: postnatal adult; Tmem204tm1.1Ali/Tmem204+ (more )
Structure Level Pattern Image Note
TS28: lymphatic vessel Present Regionally restricted 3B Clp24 +/-
TS28: tongue Present Regionally restricted 3B Clp24 +/-
Specimen 3C Clp24-/-: postnatal adult; Tmem204tm1.1Ali/Tmem204tm1.1Ali (more )
Structure Level Pattern Image Note
TS28: lymphatic vessel Present Regionally restricted 3C Clp24 -/- Authors report enlarged lymphatic vessels.
TS28: small intestine Present Regionally restricted 3C Clp24 -/- Authors report enlarged lymphatic vessels.
Specimen 3C Clp24+/-: postnatal adult; Tmem204tm1.1Ali/Tmem204+ (more )
Structure Level Pattern Image Note
TS28: lymphatic vessel Present Regionally restricted 3C Clp24 +/-
TS28: small intestine Present Regionally restricted 3C Clp24 +/-
Specimen S6A: postnatal adult; Tmem204tm1.1Ali/Tmem204tm1.1Ali (more )
Note: Triple labeled: white - Lyve1; green - Vegfr2 (Kdr assay MGI:6501773); red - alpha smooth muscle actin (Acta2 assay MGI:6501774).
Structure Level Pattern Image Note
TS28: ear Present Regionally restricted S6A LYVE-1 , S6A merge Expression is downregulated in lymphatic vessels at sites in contact with smooth muscle cells.
TS28: lymphatic vessel Present Regionally restricted S6A LYVE-1 , S6A merge Expression is downregulated in lymphatic vessels at sites in contact with smooth muscle cells.
Specimen S6B: postnatal adult (more )
Note: Triple labeled: white - Lyve1; green - Vegfr2 (Kdr assay MGI:6501773); red - alpha smooth muscle actin (Acta2 assay MGI:6501774).
Structure Level Pattern Image Note
TS28: ear Present Regionally restricted S6B merge , S6B LYVE-1
TS28: lymphatic vessel Present Regionally restricted S6B merge , S6B LYVE-1
Specimen S7A: postnatal adult; Tmem204tm1Ali/Tmem204tm1Ali, Tg(Tie1-cre)9Ref/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: ear Present Regionally restricted S7A Authors report lymphatic phenotype similar to that of Cp24-/- mice.
TS28: lymphatic vessel Present Regionally restricted S7A Authors report lymphatic phenotype similar to that of Cp24-/- mice.
Specimen S7B: postnatal adult (more )
Note: wild type
Structure Level Pattern Image Note
TS28: ear Present Regionally restricted S7B
TS28: lymphatic vessel Present Regionally restricted S7B
Specimen S8A: postnatal adult (more )
Structure Level Pattern Image Note
TS28: ear Present Regionally restricted S8A
TS28: lymphatic vessel Present Regionally restricted S8A
Specimen S8B: postnatal adult; Tmem204tm1.1Ali/Tmem204tm1.1Ali (more )
Structure Level Pattern Image Note
TS28: ear Present Regionally restricted S8B Authors report increase in expressing area compared to wild type.
TS28: lymphatic vessel Present Regionally restricted S8B Authors report increase in expressing area compared to wild type.
Specimen S8C: postnatal adult; Flt4tm1Ali/Flt4+, Tmem204tm1.1Ali/Tmem204+ (more )
Structure Level Pattern Image Note
TS28: ear Present Regionally restricted S8C Authors report increase in expressing area compared to wild type.
TS28: lymphatic vessel Present Regionally restricted S8C Authors report increase in expressing area compared to wild type.
Specimen S8D: postnatal adult; Flt4tm1Ali/Flt4+, Tmem204tm1.1Ali/Tmem204tm1.1Ali (more )
Structure Level Pattern Image Note
TS28: ear Present Regionally restricted S8D Authors report lymphatic vessels more dilated in Vegfr3+/LacZ background.
TS28: lymphatic vessel Present Regionally restricted S8D Authors report lymphatic vessels more dilated in Vegfr3+/LacZ background.
Specimen S8E: postnatal adult; Kdrtm1Jrt/Kdr+ (more )
Structure Level Pattern Image Note
TS28: ear Present Regionally restricted S8E Authors report increase in expressing area compared to wild type.
TS28: lymphatic vessel Present Regionally restricted S8E Authors report increase in expressing area compared to wild type.
Specimen S8F: postnatal adult; Kdrtm1Jrt/Kdr+, Tmem204tm1.1Ali/Tmem204tm1.1Ali (more )
Structure Level Pattern Image Note
TS28: ear Present Regionally restricted S8F Authors report lymphatic vessels more dilated in Vegfr3+/LacZ background.
TS28: lymphatic vessel Present Regionally restricted S8F Authors report lymphatic vessels more dilated in Vegfr3+/LacZ background.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory