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Gene Expression Data
Assay Details
Assay
Reference: J:276296 Chiba Y, et al., The transcription factor AmeloD stimulates epithelial cell motility essential for tooth morphology. J Biol Chem. 2019 Mar 8;294(10):3406-3418
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6488450
Gene symbol: Cdh1
Gene name: cadherin 1
Antibody: anti-E-cadherin
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 5A WT: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: enamel epithelium Strong Regionally restricted 5A upper Expressed in the ameloblasts. Not expressed in the early stage of inner enamel epithelium cells.
TS27: stratum intermedium Present 5A upper
TS27: inner enamel epithelium Absent 5A upper
Specimen 5A KO: postnatal day 1; Ascl5em1Yoya/Ascl5em1Yoya (more )
Structure Level Pattern Image Note
TS27: cervical loop Present 5A lower
TS27: inner enamel epithelium Present 5A lower
TS27: stratum intermedium Present 5A lower Similar as in the wild-type.
Specimen 7A WT: embryonic day 16.0 (more )
Note: Double labeled: green - Cdh1; red - Cdh2 (assay MGI:6488452).
Structure Level Pattern Image Note
TS24: enamel epithelium Present 7A WT left , 7A WT middle
TS24: inner enamel epithelium Present 7A WT left , 7A WT middle
Specimen 7A KO: embryonic day 16.0; Sp6tm1Yoya/Sp6tm1Yoya (more )
Note: Double labeled: green - Cdh1; red - Cdh2 (assay MGI:6488452).
Structure Level Pattern Image Note
TS24: enamel epithelium Present Regionally restricted 7A KO left , 7A KO middle Reduced expression in the invading epithelia in the presumptive inner enamel epithelium region.
TS24: inner enamel epithelium Present 7A KO middle , 7A KO left Reduced expression in the invading epithelia in the presumptive inner enamel epithelium region.
Specimen 8E Epfn KO: postnatal day 1; Sp6tm1Yoya/Sp6tm1Yoya (more )
Structure Level Pattern Image Note
TS27: inner enamel epithelium Absent 8Ea , 8Eb
TS27: molar epithelium Present Regionally restricted 8Ea , 8Eb Not expressed in the inner enamel epithelium.
Specimen 8E AmeloD;Epfn KO: postnatal day 1; Ascl5em1Yoya/Ascl5em1Yoya, Sp6tm1Yoya/Sp6tm1Yoya (more )
Structure Level Pattern Image Note
TS27: molar epithelium Present 8Ec , 8Ed
TS27: inner enamel epithelium Strong 8Ed , 8Ec
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory