Ascl5^em1Yoya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ascl5^em1Yoya
• Name: achaete-scute family bHLH transcription factor 5; endonuclease-mediated mutation 1, Yoshihiko Yamada
• MGI ID: MGI:6488415
• Gene: Ascl5 Location: Chr1:135978542-135979108 bp, + strand Genetic Position: Chr1, 59.54 cM
• Alliance: Ascl5^em1Yoya page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: ZFN-targeting of exon 2 deleted a single nucleotide (CCCCC to CCCC) and generated a frameshift and premature termination at amino acid 19. (J:276296)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ascl5 Mutation: 2 strains or lines available

References

• Original: J:276296 Chiba Y, et al., The transcription factor AmeloD stimulates epithelial cell motility essential for tooth morphology. J Biol Chem. 2019 Mar 8;294(10):3406-3418
• All: 2 reference(s)