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Gene Expression Data
Assay Details
Assay
Reference: J:276296 Chiba Y, et al., The transcription factor AmeloD stimulates epithelial cell motility essential for tooth morphology. J Biol Chem. 2019 Mar 8;294(10):3406-3418
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6488445
Gene symbol: Ascl5
Gene name: achaete-scute family bHLH transcription factor 5
Antibody: anti-AmeloD
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1 E12: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: oral region epithelium Present Regionally restricted 1_E12 Expressed in the thickening dental epithelium.
TS20: tooth Present Regionally restricted 1_E12 Expressed in the thickening dental epithelium.
Specimen 1 E14: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: inner enamel epithelium Present Regionally restricted 1_E14 Expressed in the invaginating epithelium.
TS22: molar epithelium Present Regionally restricted 1_E14 Expressed in the invaginating epithelium.
Specimen 1 E17: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: inner enamel epithelium Present 1_E17
Specimen 1 P10: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: inner enamel epithelium Strong Regionally restricted 1_P10 Expressed in the apical root tip, but not in the differentiated ameloblasts.
Specimen 2E WT: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: inner enamel epithelium Present 2E upper
Specimen 2E KO: postnatal day 1; Ascl5em1Yoya/Ascl5em1Yoya (more )
Structure Level Pattern Image Note
TS27: inner enamel epithelium Absent 2E lower
Specimen 7C WT: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: inner enamel epithelium Present 7Ca , 7Cb
Specimen 7C KO: embryonic day 17.0; Sp6tm1Yoya/Sp6tm1Yoya (more )
Structure Level Pattern Image Note
TS25: incisor epithelium Strong 7Cd , 7Cc Ectopic cervical looplike structure to form multiple incisors.
Specimen 7D WT: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: inner enamel epithelium Present 7Da , 7Db
Specimen 7D KO: embryonic day 17.0; Sp6tm1Yoya/Sp6tm1Yoya (more )
Structure Level Pattern Image Note
TS25: molar epithelium Strong 7Dd , 7Dc The dental epithelium started to form multiple branches by random invasion into mesenchyme.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory