Upk1b RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:288446 Christians A, et al., Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies. Hum Mol Genet. 2020 May 8;29(7):1192-1204
Assay type:	RNA in situ
MGI Accession ID:	MGI:6472983
Gene symbol:	Upk1b
Gene name:	uroplakin 1B

Probe:	Upk1b probe1
Probe preparation:	Antisense RNA

Results

Specimen 1B +/+: embryonic day 18.5 (more

)

Structure	Level	Image
TS26: superficial cell layer of ureter	Strong	1B left +/+
TS26: intermediate cell layer of ureter	Weak	1B left +/+
TS26: basal cell layer of ureter	Absent	1B left +/+

Specimen 1B -/-: embryonic day 18.5; Lifr^tm1Imx/Lifr^tm1Imx (more

)

Structure	Level	Image	Note
TS26: superficial cell layer of ureter	Strong	1B left -/-	Similar as in the wild-type. A narrowed ureteral lumen and positive cells located in the lumen were seen. The adluminal cell layer showed some discontinuity in the expression of the marker.
TS26: intermediate cell layer of ureter	Weak	1B left -/-	Similar as in the wild-type. A narrowed ureteral lumen and positive cells located in the lumen were seen.
TS26: basal cell layer of ureter	Absent	1B left -/-

Specimen 2 +/+: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: superficial cell layer of bladder urothelium	Present		2_left lower +/+ , 2_left upper +/+

Specimen 2 -/-: embryonic day 18.5; Lifr^tm1Imx/Lifr^tm1Imx (more

)

Structure	Level	Pattern	Image	Note
TS26: superficial cell layer of bladder urothelium	Present		2_left lower -/- , 2_left upper -/-	A thickened and ruffled epithelium with reduced and patchy expression and luminal shedding, compared with the wild-type.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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