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Gene Expression Data
Assay Details
Assay
Reference: J:288446 Christians A, et al., Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies. Hum Mol Genet. 2020 May 8;29(7):1192-1204
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6472978
Gene symbol: Upk1b
Gene name: uroplakin 1B
Antibody: anti-Upk1b (clone 1E1; WH0007348M2)
Detection system: Alexa Fluor 555
Results
Specimen 1A E14.5 +/+: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: intermediate cell layer of ureter Absent 1A right E14.5 +/+ No expression in the mono-layered urothelium.
Specimen 1A E14.5 -/-: embryonic day 14.5; Lifrtm1Imx/Lifrtm1Imx (more )
Structure Level Pattern Image Note
TS22: intermediate cell layer of ureter Absent 1A right E14.5 -/- No expression in the mono-layered urothelium, similar as in the wild-type. A narrowed ureteral lumen was seen.
Specimen 1A E16.5 +/+: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: superficial cell layer of ureter Present Regionally restricted 1A right E16.5 +/+ Apically located in a a two-layered urothelium.
Specimen 1A E16.5 -/-: embryonic day 16.5; Lifrtm1Imx/Lifrtm1Imx (more )
Structure Level Pattern Image Note
TS24: superficial cell layer of ureter Present Regionally restricted 1A right E16.5 -/- Apically located in a a two-layered urothelium, similar as in the wild-type. A narrowed ureteral lumen was seen.
Specimen 1A E18.5 +/+: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: intermediate cell layer of ureter Weak 1A right E18.5 +/+
TS26: superficial cell layer of ureter Strong 1A right E18.5 +/+
TS26: basal cell layer of ureter Absent 1A right E18.5 +/+
Specimen 1A E18.5 -/-: embryonic day 18.5; Lifrtm1Imx/Lifrtm1Imx (more )
Structure Level Pattern Image Note
TS26: basal cell layer of ureter Absent 1A right E18.5 -/-
TS26: superficial cell layer of ureter Strong 1A right E18.5 -/- Similar as in the wild-type. A narrowed ureteral lumen and cells located in the lumen were seen.
TS26: intermediate cell layer of ureter Weak 1A right E18.5 -/- Similar as in the wild-type. A narrowed ureteral lumen and cells located in the lumen were seen.
Specimen 1B +/+: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: superficial cell layer of ureter Strong 1B right +/+
TS26: intermediate cell layer of ureter Weak 1B right +/+
TS26: basal cell layer of ureter Absent 1B right +/+
Specimen 1B -/-: embryonic day 18.5; Lifrtm1Imx/Lifrtm1Imx (more )
Structure Level Pattern Image Note
TS26: basal cell layer of ureter Absent 1B right -/-
TS26: superficial cell layer of ureter Strong 1B right -/- Similar as in the wild-type. A narrowed ureteral lumen and positve cells located in the lumen were seen. The adluminal cell layer showed some discontinuity in the expression of the marker.
TS26: intermediate cell layer of ureter Weak 1B right -/- Similar as in the wild-type. A narrowed ureteral lumen and positve cells located in the lumen were seen.
Specimen 2 +/+: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: superficial cell layer of bladder urothelium Present 2_right UPK1B lower +/+ , 2_right UPK1B upper +/+
Specimen 2 -/-: embryonic day 18.5; Lifrtm1Imx/Lifrtm1Imx (more )
Structure Level Pattern Image Note
TS26: superficial cell layer of bladder urothelium Present 2_right UPK1B lower -/- , 2_right UPK1B upper -/- A thickened and ruffled epithelium with reduced and patchy expression and luminal shedding, compared with the wild-type.
Specimen 3A Proxiaml +/+: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: superficial cell layer of ureter Strong 3A left lower +/+
TS26: intermediate cell layer of ureter Weak 3A left lower +/+
TS26: basal cell layer of ureter Absent 3A left lower +/+
Specimen 3A Proxiaml -/-: embryonic day 18.5; Lifrtm1Imx/Lifrtm1Imx (more )
Structure Level Pattern Image Note
TS26: superficial cell layer of ureter Strong 3A left lower -/- Slightly increased numbers of Upk1b+Trp63-Krt5- cells, compared with the wild-type.
TS26: intermediate cell layer of ureter Weak 3A left lower -/- Significantly decreased numbers of Upk1b+Trp63+ cells, compared with the wild-type.
TS26: basal cell layer of ureter Absent 3A left lower -/-
Specimen 3A Distal +/+: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: superficial cell layer of ureter Strong 3A right lower +/+
TS26: intermediate cell layer of ureter Weak 3A right lower +/+
TS26: basal cell layer of ureter Absent 3A right lower +/+
Specimen 3A Distal -/-: embryonic day 18.5; Lifrtm1Imx/Lifrtm1Imx (more )
Structure Level Pattern Image Note
TS26: superficial cell layer of ureter Strong 3A right lower -/- Slightly increased numbers of Upk1b+Trp63-Krt5- cells, compared with the wild-type.
TS26: intermediate cell layer of ureter Weak 3A right lower -/- Significantly decreased numbers of Upk1b+Trp63+ cells, compared with the wild-type.
TS26: basal cell layer of ureter Absent 3A right lower -/-
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory