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Gene Expression Data
Assay Details
Assay
Reference: J:143548 Himes AD, et al., Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1. Dev Biol. 2009 Jan 1;325(1):151-61
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6471711
Gene symbol: Pomc
Gene name: pro-opiomelanocortin-alpha
Antibody: anti-ACTH
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 2E: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: adenohypophysis pars anterior Present 2E Expression restricted to anterior lobe.
Specimen 2F: embryonic day 14.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS22: adenohypophysis pars anterior Present 2F Expression restricted to anterior lobe.
Specimen 2G: embryonic day 14.5; Prop1df/Prop1df (more )
Structure Level Pattern Image Note
TS22: adenohypophysis pars anterior Present 2G Expression restricted to anterior lobe.
Specimen 2H: embryonic day 14.5; Hes1tm1Fgu/Hes1tm1Fgu, Prop1df/Prop1df (more )
Structure Level Pattern Image Note
TS22: remnant of Rathke's pouch Present Widespread 2H Expressing cells in ventral part of Rathke's pouch and additionally located ectopically in dorsocaudal and dorsorostral Rathke's pouch.
Specimen S1A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: adenohypophysis pars anterior Present S1A Expression restricted to anterior lobe in ventral pituitary.
Specimen S1B: embryonic day 13.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS21: adenohypophysis pars anterior Present S1B Expression restricted to anterior lobe in ventral pituitary.
Specimen S1C: embryonic day 13.5; Prop1df/Prop1df (more )
Structure Level Pattern Image Note
TS21: adenohypophysis pars anterior Present S1C Expression restricted to anterior lobe in ventral pituitary.
Specimen S1D: embryonic day 13.5; Hes1tm1Fgu/Hes1tm1Fgu, Prop1df/Prop1df (more )
Structure Level Pattern Image Note
TS21: adenohypophysis pars anterior Present S1D
TS21: remnant of Rathke's pouch Present Regionally restricted S1D Expression within and along lateral sides of Rathke's pouch.
Specimen E12.5 Wildtype not shown: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: pituitary gland Present Authors report no difference among wildtype, Hes1 mutant, Prop1 mutant or double mutant pituitary.
Specimen E12.5 Hes1 mutant not shown: embryonic day 12.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS20: pituitary gland Present Authors report no difference among wildtype, Hes1 mutant, Prop1 mutant or double mutant pituitary.
Specimen E12.5 Prop1 mutant not shown: embryonic day 12.5; Prop1df/Prop1df (more )
Structure Level Pattern Image Note
TS20: pituitary gland Present Authors report no difference among wildtype, Hes1 mutant, Prop1 mutant or double mutant pituitary.
Specimen E12.5 Double mutant not shown: embryonic day 12.5; Hes1tm1Fgu/Hes1tm1Fgu, Prop1df/Prop1df (more )
Structure Level Pattern Image Note
TS20: pituitary gland Present Authors report no difference among wildtype, Hes1 mutant, Prop1 mutant or double mutant pituitary.
Specimen 2I: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: adenohypophysis pars anterior Present Regionally restricted 2I Expression in corticotropes in anterior lobe.
TS24: adenohypophysis pars intermedia Present Regionally restricted 2I Expression in melanotrpopes in intermediate lobe.
Specimen 2J: embryonic day 16.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS24: adenohypophysis pars anterior Present Regionally restricted 2J Expression in corticotropes in anterior lobe.
TS24: adenohypophysis pars intermedia Absent 2J
Specimen 2K: embryonic day 16.5; Prop1df/Prop1df (more )
Structure Level Pattern Image Note
TS24: adenohypophysis pars anterior Present Regionally restricted 2K Authors state expression appears similar to that of the wildtype pituitary.
TS24: adenohypophysis pars intermedia Ambiguous 2K Authors state expression appears similar to that of the wildtype pituitary.
Specimen 2L: embryonic day 16.5; Hes1tm1Fgu/Hes1tm1Fgu, Prop1df/Prop1df (more )
Structure Level Pattern Image Note
TS24: adenohypophysis pars anterior Present Widespread 2L Expression throughout anterior lobe.
TS24: remnant of Rathke's pouch Present Widespread 2L Expression throughout an indistinguishable Rathke's pouch.
TS24: pituitary gland Present Widespread 2L Expression throughout entire pituitary gland.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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