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Gene Expression Data
Assay Details
Assay
Reference: J:293791 Ngo J, et al., Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation. Dev Biol. 2020 Aug 15;464(2):161-175
Assay type: RNA in situ
MGI Accession ID: MGI:6470955
Gene symbol: T
Gene name: brachyury, T-box transcription factor T
Results
Specimen 1A: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 1A Expression restricted to posterior of embryo.
Specimen 1B: embryonic day 7.5; Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Widespread 1B Excessive accumulation of expressing cells in posterior region, leading to widespread expression throughout embryo.
Specimen 1C: embryonic day 7.5; Dvl1tm1Awb/Dvl1+, Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 1C Proximal expression indicative of abnormal anterior-posterior axis specification.
Specimen 1C': embryonic day 7.5; Dvl1tm1Awb/Dvl1+, Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 1C' Proximal expression indicative of abnormal anterior-posterior axis specification.
Specimen 1D (left): embryonic day 7.5; Dvl1tm1Awb/Dvl1+, Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 1D (left) Expressing cells clustered in proximal posterior region, suggesting anterior-posterior axis was established, but mesodermal cells were defective in migrating out of primitive streak.
Specimen 1D' (left): embryonic day 7.5; Dvl1tm1Awb/Dvl1+, Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 1D' (left) Expressing cells clustered in proximal posterior region, suggesting anterior-posterior axis was established, but mesodermal cells were defective in migrating out of primitive streak.
Specimen 1D (right): embryonic day 7.5; Dvl1tm1Awb/Dvl1+, Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 1D (right) Expressing cells clustered in proximal posterior region, suggesting anterior-posterior axis was established, but mesodermal cells were defective in migrating out of primitive streak.
Specimen 1D' (right): embryonic day 7.5; Dvl1tm1Awb/Dvl1+, Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 1D' (right) Expressing cells clustered in proximal posterior region, suggesting anterior-posterior axis was established, but mesodermal cells were defective in migrating out of primitive streak.
Specimen 1E (left): embryonic day 7.5; Dvl1tm1Awb/Dvl1+, Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 1E (left) Authors report disorganization of anterior ectoderm and abnormal embryo patterning.
Specimen 1E' (left): embryonic day 7.5; Dvl1tm1Awb/Dvl1+, Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 1E' (left) Authors report disorganization of anterior ectoderm and abnormal embryo patterning.
Specimen 1E (right): embryonic day 7.5; Dvl1tm1Awb/Dvl1+, Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 1E (right) Authors report disorganization of anterior ectoderm and abnormal embryo patterning.
Specimen 1E' (right): embryonic day 7.5; Dvl1tm1Awb/Dvl1+, Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo mesoderm Present Regionally restricted 1E' (right) Authors report disorganization of anterior ectoderm and abnormal embryo patterning.
Specimen 1F (left): embryonic day 7.5; Dvl1tm1Awb/Dvl1tm1Awb, Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo Absent 1F (left) Authors report completely lack of expression.
Specimen 1F' (left): embryonic day 7.5; Dvl1tm1Awb/Dvl1tm1Awb, Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo Absent 1F' (left) Authors report completely lack of expression.
Specimen 1F (right): embryonic day 7.5; Dvl1tm1Awb/Dvl1tm1Awb, Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo Absent 1F (right) Authors report completely lack of expression.
Specimen 1F' (right): embryonic day 7.5; Dvl1tm1Awb/Dvl1tm1Awb, Dvl2tm1Awb/Dvl2tm1Awb, Dvl3tm1Awb/Dvl3tm1Awb (more )
Structure Level Pattern Image Note
TS11: embryo Absent 1F' (right) Authors report completely lack of expression.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory