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Gene Expression Data
Assay Details
Assay
Reference: J:292139 Dos-Santos Carvalho S, et al., Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth. Elife. 2020 Jan 7;9:e51822
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6460050
Gene symbol: Nefm
Gene name: neurofilament, medium polypeptide
Antibody: anti-neurofilament clone 2H3
Detection system: Secondary antibody
Results
Specimen 1 S1C - control: embryonic day 13.5 (more )
Note: littermate control; coronal section
Structure Level Pattern Image Note
TS21: brain Present 1 S1C Control Expression is seen in the fibers of the internal capsule.
Specimen 1 S1C - cKO: embryonic day 13.5; Vangl2tm1.1Djhe/Vangl2tm1.1Djhe, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. coronal section
Structure Level Pattern Image Note
TS21: brain Present 1 S1C Vangl2 cKO Expression is seen in the fibers of the internal capsule; it appears unaffected in the mutants.
Specimen 1 S1E - ventral control: postnatal day 21 (more )
Note: littermate control; horizontal section
Structure Level Pattern Image Note
TS28: corpus callosum Present 1 S1E Control Ventral
TS28: hippocampal commissure Present 1 S1E Control Ventral
Specimen 1 S1E - ventral cKO: postnatal day 21; Vangl2tm1.1Djhe/Vangl2tm1.1Djhe, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. horizontal section
Structure Level Pattern Image Note
TS28: corpus callosum Present 1 S1E Vangl2 cKO Ventral
TS28: hippocampal commissure Present 1 S1E Vangl2 cKO Ventral
Specimen 1 S1E - dorsal control: postnatal day 21 (more )
Note: littermate control; horizontal section
Structure Level Pattern Image Note
TS28: corpus callosum Present 1 S1E Control Dorsal
TS28: hippocampal commissure Present 1 S1E Control Dorsal
Specimen 1 S1E - dorsal cKO: postnatal day 21; Vangl2tm1.1Djhe/Vangl2tm1.1Djhe, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. horizontal section
Structure Level Pattern Image Note
TS28: corpus callosum Absent 1 S1E Vangl2 cKO Dorsal Although present ventrally, there is an agensis of both the corpus collosum and hippocampal commissure in the dorso-caudal region of the forebrain. Other major commissures appeared intact.
TS28: hippocampal commissure Absent 1 S1E Vangl2 cKO Dorsal Although present ventrally, there is an agensis of both the corpus collosum and hippocampal commissure in the dorso-caudal region of the forebrain. Other major commissures appeared intact.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory