Vangl2^tm1.1Djhe
Targeted Allele Detail

Summary

• Symbol: Vangl2^tm1.1Djhe
• Name: VANGL planar cell polarity 2; targeted mutation 1.1, Deborah J Henderson
• MGI ID: MGI:6437372
• Synonyms: Vangl2^flox
• Gene: Vangl2 Location: Chr1:171828527-171856011 bp, - strand Genetic Position: Chr1, 79.54 cM
• Alliance: Vangl2^tm1.1Djhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228847
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was flanked by loxP sites and an FRT-flanked Neo-PGK cassette was inserted downstream of the floxed exon 4. Flp-mediated recombination removed the selection cassette. (J:228847)

Expression

In Mice Carrying this Mutation:

13 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vangl2 Mutation: 34 strains or lines available

References

• Original: J:228847 Ramsbottom SA, et al., Vangl2-regulated polarisation of second heart field-derived cells is required for outflow tract lengthening during cardiac development. PLoS Genet. 2014 Dec;10(12):e1004871
• All: 11 reference(s)