About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:76173 Vitelli F, et al., Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways. Hum Mol Genet. 2002 Apr 15;11(8):915-22
Assay type: RNA in situ
MGI Accession ID: MGI:6459260
Gene symbol: Crabp1
Gene name: cellular retinoic acid binding protein I
Probe: lambda-mE1.3
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 3A: embryonic day 9.5; Tbx1tm1Bld/Tbx1+ (more )
Structure Level Pattern Image Note
TS15: migrating neural crest Present Regionally restricted 3A Expression in neural crest cells exiting neural tube.
TS15: 2nd branchial arch mesenchyme derived from neural crest Present 3A Expression in neural crest cells invading 2nd and 3rd arches.
TS15: 3rd branchial arch mesenchyme derived from neural crest Present 3A Expression in neural crest cells invading 2nd and 3rd arches.
TS15: head mesenchyme derived from neural crest Present Regionally restricted 3A Expression in circumpharyngeal region.
Specimen 3B: embryonic day 9.5; Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld (more )
Structure Level Pattern Image Note
TS15: migrating neural crest Present Regionally restricted 3B Neural crest cells initially migrate out of neural tube in appropriate streams, but shown abnormal distribution in pharyngeal region. Expression in scattered ectopic neural crest cells.
TS15: 2nd branchial arch mesenchyme derived from neural crest Present Regionally restricted 3B Expression in pre-otic stream of cells entering hypoplastic arch.
TS15: head mesenchyme derived from neural crest Present Regionally restricted 3B Authores report absence of caudal expression domain.
Specimen 3C: embryonic day 10.0; Tbx1tm1Bld/Tbx1+ (more )
Structure Level Pattern Image Note
TS16: migrating neural crest Present Regionally restricted 3C Circumpharyngeal stream proceeds caudal to the 4th arch.
TS16: 4th branchial arch mesenchyme derived from neural crest Present 3C
Specimen 3D: embryonic day 10.0; Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld (more )
Structure Level Pattern Image Note
TS16: migrating neural crest Present Regionally restricted 3D Misdirected neural crest cell streams wrap around otocyst. Expression in ectopic neural crest cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory