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Gene Expression Data
Assay Details
Assay
Reference: J:189955 Star EN, et al., Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6. Development. 2012 Dec;139(24):4644-55
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6450541
Gene symbol: Syt2
Gene name: synaptotagmin II
Antibody: znp-1
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 5C: postnatal month 2-3; Irx6tm1Chow/Irx6+ (more )
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Present Regionally restricted 5C Expression was detected in type 2 and 6 bipolar cells.
TS28: retina inner plexiform layer Present Regionally restricted 5C Expression was detected in axon termini.
Specimen 5D: postnatal month 2-3; Irx6tm1Chow/Irx6tm1Chow (more )
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Weak Regionally restricted 5D Expression in bipolar cells was greatly reduced in the mutant.
TS28: retina inner plexiform layer Weak Regionally restricted 5D Reduced immunolabeling of axon termini was observed in the inner plexiform layer for both type 2 and 6 bipolar cells.
Specimen S3B: postnatal month 2-3; Irx6tm1Chow/Irx6tm1Chow (more )
Note: Double labeled: red - Syt2; green - Irx6 (assay MGI:6450171).
Structure Level Pattern Image Note
TS28: retina inner plexiform layer Present Regionally restricted S3C , S3B Syt2 immunolabeled axons in the upper and lower zones of the inner plexiform layer corresponding to the OFF and ON projecting region were co-labeled with Irx6:beta-gal.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/30/2025
MGI 6.24 		The Jackson Laboratory