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Gene Expression Data
Assay Details
Assay
Reference: J:199297 Kitagawa M, et al., Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development. Mech Dev. 2013 Sep-Oct;130(9-10):458-66
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6441783
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: anti-PECAM1
Detection system: horseradish peroxidase
Results
Specimen 1C: embryonic day 10.5; Hes1tm1Kag/Hes1+, Hes5tm1Fgu/Hes5tm1Fgu (more )
Structure Level Pattern Image Note
TS17: brain vascular element Present 1C
Specimen Hes1 KO not shown: embryonic day 10.5; Hes1tm1Fgu/Hes1tm1Fgu (more )
Structure Level Pattern Image Note
TS17: brain vascular element Present Microvascular networks over the brain were abnormal compared with control; but with no phenotype in vascular development.
Specimen 1D: embryonic day 10.5; Hes1tm1Fgu/Hes1tm1Fgu, Hes5tm1Fgu/Hes5tm1Fgu (more )
Structure Level Pattern Image Note
TS17: brain vascular element Present Regionally restricted 1D Large major branches of internal carotid were decreased in number, and small branches were increased compared with control
Specimen 1E: embryonic day 10.5; Hes1tm1Fgu/Hes1tm1Fgu, Hes5tm1Fgu/Hes5tm1Fgu (more )
Structure Level Pattern Image Note
TS17: brain vascular element Present Regionally restricted 1E Abnormal microvascular networks over the brain and vascular malformations (abnormal angiomas) were observed.
Specimen 3A: embryonic day 10.5; Hes1tm1Kag/Hes1+, Hes5tm1Fgu/Hes5tm1Fgu (more )
Structure Level Pattern Image Note
TS17: brain vascular element Present 3A
TS17: internal carotid artery Present 3A
Specimen 3B: embryonic day 10.5; Hes1tm1Fgu/Hes1tm1Kag, Hes5tm1Fgu/Hes5tm1Fgu, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain vascular element Present Regionally restricted 3B Large major branches of internal carotid were decreased in number compared with control.
TS17: internal carotid artery Present 3B Internal carotid artery significantly increased in diameter.
Specimen 3C: embryonic day 10.5; Hes1tm1Kag/Hes1+, Hes5tm1Fgu/Hes5tm1Fgu (more )
Structure Level Pattern Image Note
TS17: brain vascular element Present 3C
Specimen 3D: embryonic day 10.5; Hes1tm1Fgu/Hes1tm1Kag, Hes5tm1Fgu/Hes5tm1Fgu, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain vascular element Present Regionally restricted 3D Small branches were increased in number compared with control. Abnormal microvascular networks were observed.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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