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Gene Expression Data
Assay Details
Assay
Reference: J:245637 Xu YW, et al., Maternal DCAF2 is crucial for maintenance of genome stability during the first cell cycle in mice. J Cell Sci. 2017 Oct 01;130(19):3297-3307
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6437829
Gene symbol: H2ax
Gene name: H2A.X variant histone
Results
Specimen 2A WT PN3: embryonic day 0.5 (more )
Note: pronucleus (PN)-3 stage
Structure Level Pattern Image Note
TS1: 1-cell stage embryo Absent 2A WT PN3
Specimen 2A WT PN4: embryonic day 0.5 (more )
Note: pronucleus (PN)-4 stage
Structure Level Pattern Image Note
TS1: 1-cell stage embryo Present 2A WT PN4 Showing DNA damage in the nuclei.
Specimen 2A WT PN5: embryonic day 0.5 (more )
Note: pronucleus (PN)-5 stage
Structure Level Pattern Image Note
TS1: 1-cell stage embryo Weak 2A WT PN5
Specimen 2A cKO PN5: embryonic day 0.5; Dtltm1c(EUCOMM)Wtsi/Dtltm1c(EUCOMM)Wtsi, Tg(Gdf9-icre)5092Coo/0 (more )
Note: Conditional mutant. pronucleus (PN)-5 stage
Structure Level Pattern Image Note
TS1: 1-cell stage embryo Present 2A cKO Stronger expression compared with the PN5 wild-type.
Specimen 2B WT: embryonic day 1.0 (more )
Note: 2-cell stage embryo
Structure Level Pattern Image Note
TS2: 2-cell stage embryo Absent 2B WT DNA damage was repaired.
Specimen 2B cKO left: embryonic day 0.5; Dtltm1c(EUCOMM)Wtsi/Dtltm1c(EUCOMM)Wtsi, Tg(Gdf9-icre)5092Coo/0 (more )
Note: Conditional mutant. delayed development, arrested at the zygote stage
Structure Level Pattern Image Note
TS1: 1-cell stage embryo Present 2B cKO left Delayed development, arrested at the zygote stage.
Specimen 2B cKO right: embryonic day 1.0; Dtltm1c(EUCOMM)Wtsi/Dtltm1c(EUCOMM)Wtsi, Tg(Gdf9-icre)5092Coo/0 (more )
Note: Conditional mutant. 2-cell stage embryo
Structure Level Pattern Image Note
TS2: 2-cell stage embryo Strong 2B cKO right Expressed in nuclei in occasionally seen the two-cell stage mutant.
Specimen 5B PN3: embryonic day 0.5; Ddb1tm1Spg/Ddb1tm1Spg, Tg(Gdf9-icre)5092Coo/0 (more )
Note: Conditional mutant. pronucleus (PN)-3 stage
Structure Level Pattern Image Note
TS1: 1-cell stage embryo Absent 5B PN3 No DNA damage.
Specimen 5B PN4: embryonic day 0.5; Ddb1tm1Spg/Ddb1tm1Spg, Tg(Gdf9-icre)5092Coo/0 (more )
Note: Conditional mutant. pronucleus (PN)-4 stage
Structure Level Pattern Image Note
TS1: 1-cell stage embryo Absent 5B PN4 Loss of DNA damage.
Specimen 5B PN5: embryonic day 0.5; Ddb1tm1Spg/Ddb1tm1Spg, Tg(Gdf9-icre)5092Coo/0 (more )
Note: Conditional mutant. pronucleus (PN)-5 stage
Structure Level Pattern Image Note
TS1: 1-cell stage embryo Absent 5B PN5 Loss of DNA damage.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory