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Gene Expression Data
Assay Details
Assay
Reference: J:138379 Gu S, et al., Shox2-deficiency leads to dysplasia and ankylosis of the temporomandibular joint in mice. Mech Dev. 2008 Aug;125(8):729-42
Assay type: RNA in situ
MGI Accession ID: MGI:6434464
Gene symbol: Shox2
Gene name: SHOX homeobox 2
Probe: Shox2 probe6
Probe preparation: labelled with digoxigenin RNA
Results
Specimen 2A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: brain Present 2A
TS17: limb bud Present 2A
TS17: 1st branchial arch Present Regionally restricted 2A Expression in region of maxilla-mandibular junction.
Specimen 2B: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: mandible primordium Strong Regionally restricted 2B Strong expression in mesenchymal tissue of maxilla-mandibular junction.
TS19: maxilla primordium Strong Regionally restricted 2B Strong expression in mesenchymal tissue of maxilla-mandibular junction.
Specimen E12.5 not shown: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: jaw primordium Present Regionally restricted Expression begins to decrease at E12.5.
Specimen 2C: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: mandible condylar condensation Present Regionally restricted 2C Expression restricted to progenitor cells in condylar condensation.
TS21: Meckel's cartilage Absent 2C
Specimen 2D: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: mandible condylar process Present Regionally restricted 2D Expression in progenitor cells and undifferentiated chondrocytes of developing condyle. No expression in hypertrophic chondrocytes.
TS23: mandibular fossa Present Regionally restricted 2D Expression in perichondrium and developing glenoid fossa.
TS23: Meckel's cartilage Absent 2D
Specimen E16.5 not shown: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: mandible condylar process Present Regionally restricted Expression in progenitor cells and undifferentiated chondrocytes of developing condyle. No expression in hypertrophic chondrocytes.
Specimen 3B: embryonic day 13.5; Shox2tm1Ddu/Shox2tm1Ypc, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: mandible condylar condensation Trace Regionally restricted 3B Extremely low level of expression in developing temporomandibular joint.
TS21: Meckel's cartilage Absent 3B
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory