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Gene Expression Data
Assay Details
Assay
Reference: J:165724 Yu S, et al., Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development. Dev Biol. 2010 Nov 1;347(1):92-108
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6423684
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: MEC 13.3
Results
Specimen S1C: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lung vascular element Present S1C
Specimen S1C': embryonic day 13.5; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: lung vascular element Present S1C' Authors report normal expression.
Specimen S2E: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lung vascular element Present S2E
Specimen S2E': embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lung vascular element Present S2E'
Specimen S2F: embryonic day 14.5; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: lung vascular element Present S2F Authors report normal expression.
Specimen S2F': embryonic day 14.5; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: lung vascular element Present S2F' Authors report normal expression.
Specimen S3E: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lung vascular element Present S3E
Specimen S3E': embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lung vascular element Present S3E'
Specimen S3F: embryonic day 14.5; Fgf8tm1Mrc/Fgf8tm3Mrc (more )
Structure Level Pattern Image Note
TS22: lung vascular element Present S3F
Specimen S3F': embryonic day 14.5; Fgf8tm1Mrc/Fgf8tm3Mrc (more )
Structure Level Pattern Image Note
TS22: lung vascular element Present S3F'
Specimen S3K: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lung vascular element Present S3K
Specimen S3K': embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lung vascular element Present S3K'
Specimen S3L: embryonic day 15.5; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: lung vascular element Present S3L
Specimen S3L': embryonic day 15.5; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: lung vascular element Present S3L'
Specimen 9D: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: lung vascular element Present 9D
Specimen 9D': embryonic day 16.5; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: lung vascular element Present 9D' Expression in endothelial cells appears comparable to controls.
Specimen 9E: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: lung vascular element Present 9E
Specimen 9E': embryonic day 17.5; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: lung vascular element Present 9E' Expression in endothelial cells appears normal in mutants.
Specimen 9F: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lung vascular element Present Regionally restricted 9F Expression in well-organized capillary network encompassing thin septa.
Specimen 9F': embryonic day 18.5; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: lung vascular element Weak Regionally restricted 9F' Expression in vessels that are inseptal, decreased compared with controls.
Specimen 9K: embryonic day 19.0 (more )
Structure Level Pattern Image Note
TS26: lung vascular element Present 9K
Specimen 9K': embryonic day 19.0 (more )
Structure Level Pattern Image Note
TS26: lung vascular element Present 9K'
Specimen 9L: embryonic day 19.0; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: lung vascular element Present Regionally restricted 9L Expression in fewer capillaries, and network is hypoplastic and abberrantly located withink thickened septa.
Specimen 9L': embryonic day 19.0; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: lung vascular element Present Regionally restricted 9L' Expression in fewer capillaries, and network is hypoplastic and abberrantly located withink thickened septa.
Specimen 10A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lung vascular element Present 10A
Specimen 10A': embryonic day 18.5; Fgf8tm1Mrc/Fgf8tm3Mrc (more )
Structure Level Pattern Image Note
TS26: lung vascular element Weak Regionally restricted 10A' Authors report same expression abnormalities at as in Fgf8/Isl1Cre mutants.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory