Fgf8tm3Mrc
Targeted Allele Detail
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Symbol: |
Fgf8tm3Mrc |
Name: |
fibroblast growth factor 8; targeted mutation 3, Mario R Capecchi |
MGI ID: |
MGI:2686826 |
Synonyms: |
Fgf8APN, Fgf8CR, Fgf8H, Fgf8hy |
Gene: |
Fgf8 Location: Chr19:45725237-45731354 bp, - strand Genetic Position: Chr19, 38.75 cM, cytoband C3-D
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Alliance: |
Fgf8tm3Mrc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:66265
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, Hypomorph, Reporter) |
Mutation: |
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Insertion
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Mutation details: This hypomorphic allele was generated by inserting an frt-flanked neomycin cassette into intron 5. Single loxP sites located in introns 4 and 5, flank exon 5 and the neomycin cassette. An alkaline phosphatase gene was inserted just 5' to the second lox P site such that upon cre-mediated recombination, the alkaline phosphatase gene is expressed under the control of the Fgf8 gene. Fgf8tm1Mrc and Fgf8tm2Mrc were respectively generated by cre- and flp-mediated recombination of this allele.
(J:66265, J:87304)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fgf8 Mutation: |
18 strains or lines available
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Original: |
J:66265 Moon AM, et al., Fgf8 is required for outgrowth and patterning of the limbs. Nat Genet. 2000 Dec;26(4):455-9 |
All: |
8 reference(s) |
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