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Gene Expression Data
Assay Details
Assay
Reference: J:165724 Yu S, et al., Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development. Dev Biol. 2010 Nov 1;347(1):92-108
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6423681
Gene symbol: Foxa2
Gene name: forkhead box A2
Results
Specimen S1A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lung Present S1A
Specimen S1A': embryonic day 13.5; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: lung Present S1A' Authors report normal expression.
Specimen S2A: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lung Present S2A
Specimen S2A': embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lung Present S2A'
Specimen S2B: embryonic day 14.5; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: lung Present S2B Authors report normal expression.
Specimen S2B': embryonic day 14.5; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: lung Present S2B' Authors report normal expression.
Specimen S3A: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lung Present S3A
Specimen S3A': embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lung Present S3A'
Specimen S3B: embryonic day 14.5; Fgf8tm1Mrc/Fgf8tm3Mrc (more )
Structure Level Pattern Image Note
TS22: lung Present S3B
Specimen S3B': embryonic day 14.5; Fgf8tm1Mrc/Fgf8tm3Mrc (more )
Structure Level Pattern Image Note
TS22: lung Present S3B'
Specimen S3I: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lung Present S3I
Specimen S3I': embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lung Present S3I'
Specimen S3J: embryonic day 15.5; Fgf8tm1Mrc/Fgf8tm3Mrc (more )
Structure Level Pattern Image Note
TS23: lung Present S3J Authors report normal expression.
Specimen S3J': embryonic day 15.5; Fgf8tm1Mrc/Fgf8tm3Mrc (more )
Structure Level Pattern Image Note
TS23: lung Present S3J' Authors report normal expression.
Specimen 9A: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: lung epithelium Present Regionally restricted 9A Expression in distal epithelium.
Specimen 9A': embryonic day 16.5; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: lung epithelium Present Regionally restricted 9A' Expression in distal epithelia appears comparable to controls
Specimen 9B: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: lung epithelium Weak Regionally restricted 9B Lungs have progressed to saccular stage and number of expressing cells is decreasing as immature Type II cells differentiate into Type I cells.
Specimen 9B': embryonic day 17.5; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: lung epithelium Present Regionally restricted 9B' Persistent expression in cuboidal cells surrounding rare, small airspaces.
Specimen 9C: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lung epithelium Weak Regionally restricted 9C Authors report many large airspaces.
Specimen 9C': embryonic day 18.5; Fgf8tm1Mrc/Fgf8tm2Moon, Isl1tm1(cre)Sev/Isl1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: lung epithelium Present Regionally restricted 9C' Expression in many cuboidal cells lining saccules.
Specimen 10D: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lung epithelium Weak Regionally restricted 10D
Specimen 10D': embryonic day 18.5; Fgf8tm1Mrc/Fgf8tm3Mrc (more )
Structure Level Pattern Image Note
TS26: lung epithelium Present Regionally restricted 10D' Authors report same expression abnormalities at as in Fgf8/Isl1Cre mutants.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory