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Gene Expression Data
Assay Details
Assay
Reference: J:221356 Snowball J, et al., Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall. Dev Biol. 2015 May 15;401(2):264-75
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6407011
Gene symbol: Axin2
Gene name: axin 2
Reporter: lacZ
Direct Detection
Results
Specimen 3A Control Axin2 LacZ (left): embryonic day 13.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS21: body wall Present Regionally restricted 3A Control Axin2 LacZ (left) Expression in ventral body wall converging at midline as a well-defined stripe.
Specimen 3A Control Axin2 LacZ (right): embryonic day 13.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS21: body wall Present Regionally restricted 3A Control Axin2 LacZ (right) Expression in ventral body wall converging at midline as a well-defined stripe.
Specimen 3A Wls f/f; Dermo1 Cre/+; Axin2 LacZ (left): embryonic day 13.5; Axin2tm1Wbm/Axin2+, Twist2tm1.1(cre)Dor/Twist2+, Wlstm1.1Lan/Wlstm1.1Lan (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: body wall Strong Scattered 3A Wls f/f; Dermo1 Cre/+; Axin2 LacZ (left) Expression scattered throughout ventral body wall, more intense than in control. Definitive midline expression not detected.
Specimen 3A Wls f/f; Dermo1 Cre/+; Axin2 LacZ (right): embryonic day 13.5; Axin2tm1Wbm/Axin2+, Twist2tm1.1(cre)Dor/Twist2+, Wlstm1.1Lan/Wlstm1.1Lan (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: body wall Strong Scattered 3A Wls f/f; Dermo1 Cre/+; Axin2 LacZ (right) Expression scattered throughout ventral body wall, more intense than in control. Definitive midline expression not detected.
Specimen S1 E12.5 Control Axin2 lacZ: embryonic day 12.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS20: lung Present S1_E12.5 Control Axin2 LacZ
Specimen S1 E12.5 Wls f/f;Dermo1 Cre/+; Axin2 LacZ Axin2 lacZ: embryonic day 12.5; Axin2tm1Wbm/Axin2+, Twist2tm1.1(cre)Dor/Twist2+, Wlstm1.1Lan/Wlstm1.1Lan (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: lung Weak Regionally restricted S1_E12.5 Wls f/f; Dermo Cre/+; Axin2 LacZ Expression diminished compared to controls. Lungs exhibit anomalous branching and elongated shape.
Specimen S1 E13.5 Control Axin2 LacZ: embryonic day 13.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS21: lung Present S1_E13.5 Control Axin2 LacZ
Specimen S1 E13.5 Wls f/f; Dermo1 Cre/+; Axin2 LacZ: embryonic day 13.5; Axin2tm1Wbm/Axin2+, Twist2tm1.1(cre)Dor/Twist2+, Wlstm1.1Lan/Wlstm1.1Lan (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: lung Weak Regionally restricted S1_E13.5 Wls f/f; Dermo Cre/+; Axin2 LacZ Expression diminished compared to controls. Anomalous branching and shape become more accentuated as development progresses.
Specimen S1 E14.5 Control Axin2 LacZ: embryonic day 14.5; Axin2tm1Wbm/Axin2+ (more )
Structure Level Pattern Image Note
TS22: lung Present S1_E14.5 Control Axin2 LacZ
Specimen S1 E14.5 Wls f/f; Dermo1 Cre/+; Axin2 LacZ: embryonic day 14.5; Axin2tm1Wbm/Axin2+, Twist2tm1.1(cre)Dor/Twist2+, Wlstm1.1Lan/Wlstm1.1Lan (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: lung Weak Regionally restricted S1_E14.5 Wls f/f; Dermo Cre/+; Axin2 LacZ Expression diminished compared to controls. Anomalous branching and shape become more accentuated as development progresses.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory