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Gene Expression Data
Assay Details
Assay
Reference: J:203431 Collette NM, et al., Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner. Dev Biol. 2013 Nov 1;383(1):90-105
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6406284
Gene symbol: Sost
Gene name: sclerostin
Reporter: lacZ
Direct Detection
Results
Specimen 2A: embryonic day 9.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS15: embryo Present Regionally restricted 2A

Specimen 2A': embryonic day 9.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS15: forelimb bud Present Regionally restricted 2A' Expression in distal limb bud as early as E9.5.

Specimen 2A": embryonic day 9.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS15: forelimb bud ectoderm Present 2A" Expression restricted to ectoderm.
TS15: forelimb bud mesenchyme Absent 2A"

Specimen 2B: embryonic day 10.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS17: central nervous system Present Regionally restricted 2B

Specimen 2B': embryonic day 10.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS17: forelimb bud ectoderm Present Regionally restricted 2B'
TS17: forelimb bud apical ectodermal ridge Absent 2B'

Specimen 2B": embryonic day 10.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS17: forelimb bud Present Regionally restricted 2B"

Specimen 2b: embryonic day 10.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS17: forelimb bud ectoderm Present Regionally restricted 2b
TS17: forelimb bud mesenchyme Absent 2b

Specimen 2C: embryonic day 11.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS19: embryo Present Regionally restricted 2C
TS19: central nervous system Present Regionally restricted 2C Expression in very thin layer of cells lining edge of neural folds.
TS19: future spinal cord Present Regionally restricted 2C Expression in cells at base of spinal cord at level of forelimbs.

Specimen 2C': embryonic day 11.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS19: handplate ectoderm Present Regionally restricted 2C'
TS19: handplate apical ectodermal ridge Absent 2C'

Specimen 2C": embryonic day 11.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS19: handplate Present Regionally restricted 2C"

Specimen 2c: embryonic day 11.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS19: handplate ectoderm Present Regionally restricted 2c
TS19: handplate mesenchyme Absent 2c

Specimen 2D: embryonic day 12.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS20: embryo Present Regionally restricted 2D
TS20: cerebellum primordium Present Regionally restricted 2D Expression restricted to base of cerebellum.

Specimen 2D': embryonic day 12.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS20: hand epithelium Present Regionally restricted 2D' Expression excluded from apical ectodermal ridge.

Specimen 2D": embryonic day 12.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS20: hand Present Regionally restricted 2D"

Specimen 2d: embryonic day 12.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS20: hand Present Regionally restricted 2d
TS20: hand mesenchyme Absent 2d

Specimen 2E: embryonic day 13.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS21: embryo Present Regionally restricted 2E
TS21: cerebellum Present Regionally restricted 2E Expression restricted to base of cerebellum.

Specimen 2E': embryonic day 13.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS21: hand epithelium Present Regionally restricted 2E' Expression confined to ectoderm.
TS21: limb nerve Present Regionally restricted 2E' Expression in network of axons innervating dorsal limb floank mesenchyme.

Specimen 2F: embryonic day 14.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS22: embryo Present Regionally restricted 2F

Specimen 2F': embryonic day 14.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS22: forelimb digit Weak 2F' Fainter expression restricted to digits.

Specimen 3A: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: appendicular skeleton Present 3A

Specimen 3B: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: axial skeleton Present 3B

Specimen 3C: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: limb long bone Present Regionally restricted 3C Expression in long bones primarily in osteocytes of cortical bone. Low levels of expression in osteoblasts and osteoclasts.

Specimen 3c: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: limb long bone Present Regionally restricted 3c Expression in long bones primarily in osteocytes of cortical bone.

Specimen 3D: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: articular cartilage Absent 3D
TS27: limb connective tissue Absent 3D
TS27: limb musculature Absent 3D

Specimen 3E: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: cranium Present 3E Expression in skull.

Specimen 3e: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: chondrocranium Present Regionally restricted 3e Expression localized to osteoblasts and osteocytes in calvaria.

Specimen 3F: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: mandible Present 3F

Specimen S1A: embryonic day 9.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS15: neural fold Present S1A

Specimen S1B: embryonic day 11.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS19: future spinal cord Present Regionally restricted S1B Expression at base of spinal cord at level of forelimbs in cluster of cells likely marking lateral motor neurons migrating into limb.
TS19: forelimb bud Present S1B
TS19: hindlimb bud Present S1B

Specimen S1C: embryonic day 12.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS20: spinal cord Present Regionally restricted S1C Two distinct domains of expression at base of spinal cord at level of forelimb. Expression near base of hindlimbs.

Specimen S1D: embryonic day 12.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS20: peripheral nerve Present Regionally restricted S1D Expression in cells seeming to migrate into limb.

Specimen S1E: embryonic day 13.5; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS21: limb nerve Present Regionally restricted S1E Expression corresponds to network of axons innervating dorsal limb flank mesenchyme.

Specimen S2B: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: cardiovascular system Present Regionally restricted S2B
TS27: ascending aorta Present S2B
TS27: carotid artery Present S2B Expression in ascending aorta branchies (carotid arteries).

Specimen S2b: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: carotid artery Present S2b Expression in ascending aorta branchies (carotid arteries).

Specimen S2C: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: carotid artery Present S2C Expression in ascending aorta branchies (carotid arteries).
TS27: descending aorta Present S2C

Specimen S2c: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: descending aorta Present S2c

Specimen S2D: postnatal adult; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS28: heart Present Regionally restricted S2D Expression in highly restricted cluster of cells in the heart.
TS28: ascending aorta Present Regionally restricted S2D Expression in smooth muscle of ascending aorta.

Specimen S2d: postnatal adult; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS28: heart Present Regionally restricted S2d Expression in highly restricted cluster of cells in the heart.

Specimen S2E: postnatal adult; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS28: ascending aorta Present Regionally restricted S2E Expression in smooth muscle of ascending aorta.

Specimen S2e: postnatal adult; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS28: heart Present Regionally restricted S2e Expression in two highly restricted regions of heart.

Specimen S3A: postnatal adult; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS28: bone tissue Present Regionally restricted S3A Expression in multinucleated osteoclasts near trabecular bone.

Specimen S4A: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: ductus deferens Present S4A
TS27: epididymis Present S4A

Specimen S4a: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: ductus deferens Present S4a

Specimen S4B: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: pyloric sphincter Present S4B

Specimen S4C: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: cerebellum Present Regionally restricted S4C Authors report expression in distinct regions of cerebellum.

Specimen S4c: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: cerebellum Present Regionally restricted S4c Authors report expression in distinct regions of cerebellum.

Specimen S4D: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: renal cortex Present S4D

Specimen S4d: postnatal newborn; Sosttm1Paz/Sost+ (more )
Structure Level Pattern Image Note
TS27: renal cortex Present S4d


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory