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Gene Expression Data
Assay Details
Assay
Reference: J:169673 Weston MD, et al., MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival. Dev Dyn. 2011 Apr;240(4):808-19
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6402827
Gene symbol: Myo7a
Gene name: myosin VIIA
Antibody: anti-Myo7a
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 4B P16 control base: postnatal day 16; Dicer1tm1Bdh/Dicer1+, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. Base. Double labeled: green - Myo7a; red - actin.
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Regionally restricted 4B upper left base Expressed in inner and outer hair cells.
Specimen 4B P16 control apex: postnatal day 16; Dicer1tm1Bdh/Dicer1+, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. Apex. Double labeled: green - Myo7a; red - actin.
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Regionally restricted 4B upper left apex Expressed in inner and outer hair cells.
Specimen 4B P16 CKO base: postnatal day 16; Dicer1tm1Bdh/Dicer1tm1Bdh, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. Base. Double labeled: green - Myo7a; red - actin.
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Regionally restricted 4B lower left base Expressed in inner and outer hair cells. Minor loss of outer hair cells was seen in the base.
Specimen 4B P16 CKO apex: postnatal day 16; Dicer1tm1Bdh/Dicer1tm1Bdh, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. Apex. Double labeled: green - Myo7a; red - actin.
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Regionally restricted 4B lower left apex Expressed in inner and outer hair cells. Normal histological organization and presence of hair cells.
Specimen 4B P28 control base: postnatal day 28; Dicer1tm1Bdh/Dicer1+, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. Base. Double labeled: green - Myo7a; red - actin.
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Regionally restricted 4B upper right base Expressed in inner and outer hair cells.
Specimen 4B P28 control apex: postnatal day 28; Dicer1tm1Bdh/Dicer1+, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. Base. Double labeled: green - Myo7a; red - actin.
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Regionally restricted 4B upper right apex Expressed in inner and outer hair cells.
Specimen 4B P28 CKO base: postnatal day 28; Dicer1tm1Bdh/Dicer1tm1Bdh, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. apex
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Regionally restricted 4B lower right base Expressed in inner and outer hair cells. Marked reduction in basal outer hair cells. Inner hair cells were substantially less affected.
Specimen 4B P28 CKO apex: postnatal day 28; Dicer1tm1Bdh/Dicer1tm1Bdh, Tg(Atoh1-cre)1Bfri/0 (more )
Note: Conditional mutant. apex
Structure Level Pattern Image Note
TS28: cochlea epithelium Present Regionally restricted 4B lower right apex Expressed in inner and outer hair cells. Some loss of apical outer hair cells. Inner hair cells were substantially less affected.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory